Julianne Moore won the best actress Oscar on Sunday for her role as a university professor with Alzheimer's disease in Still Alice.
The win is the veteran actress's first Academy Award after being nominated four times previously. The 54-year-old was favored to win this year's prize after picking up Golden Globe, Screen Actors Guild and BAFTA awards earlier this year
Her performance was someone trying, desperately to retain their personality and their dignity as her faculties start to fade, had been widely praised and her win had been anticipated by many.
Oscars 2015 winners
Oscars 2015 winners
1/15 Best Actor
Eddie Redmayne picks up his award for Best Actor (Robyn Beck AFP)
2/15 Best Actress
Julianne Moore picks up her award for Best Actress for her role in Still Alice (Robyn Beck AFP)
3/15 Best Picture
The cast and crew of Birdman accept their Best Picture Oscar on stage
4/15 Best Supporting Actress
5/15 Best Supporting Actress
6/15 Best Director
'Birdman': Director Alejandro Gonzalez Inarritu accepts the Best Director Award for Kevin Winter/Getty Images)
7/15 Best Screenplay
Birdman: Director Alejandro G. Irritu, Nicolas Giacobone, Alexander Dinelaris, Jr. & Armando Bo (ROBYN BECK/AFP/Getty Images)
8/15 Best Documentary Feature
CitizenFour: Laura Poitras (2nd L) embraces The Guardian journalist Glenn Greenwald (C), as Mathilde Bonnefoy (R) and Dirk Wilutzky (L) (ROBYN BECK/AFP/Getty Images)
9/15 Best Adapted Screenplay
The Imitation Game: Graham Moore (ROBYN BECK/AFP/Getty Images)
10/15 Best Production Design
The Grand Budapest Hotel: Adam Stockhausen (Production Design) and Anna Pinnock (Set Decoration) (ROBYN BECK/AFP/Getty Images)
ROBYN BECK/AFP/Getty Images
11/15 Best Visual Effects
Interstellar: Paul Franklin (2ndL) , Andrew Lockley (R) , Ian Hunter (L) and Scott Fisher (ROBYN BECK/AFP/Getty Images)
12/15 Best Animated Feature
Big Hero 6: Don Hall (C), Chris Williams (R) and Roy Conli (ROBYN BECK/AFP/Getty Images)
13/15 Best Cinematography
Birdman: Emmanuel Lubezki AFP PHOTO / Robyn BECK (ROBYN BECK/AFP/Getty Images)
14/15 Best Sound Editing
American Sniper: Alan Robert Murray (R) and Bub Asman (ROBYN BECK/AFP/Getty Images)
15/15 Best Foreign Language Film
Ida (Poland): Pawel Pawlikowski (ROBYN BECK/AFP/Getty Images)
"I'm so happy, I'm thrilled that we were able to shine a light on Alzheimer's disease," Moore said. "So many people who have this disease feel marginalised. People who have Alzheimer's disease deserve to be seen so we can find a cure."
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Moore did four months of research for her role, talking to women with the disease and doctors, and she visited a long-term care facility.
"I like stories about real people and real relationships and real families," she said backstage. "This movie had all of those things in it. It's about a real issue and relationships and who we love and what we value."