Joining them in Manchester's Heaton Park will be the likes of chart-toppers Bastille, iconic rappers Busta Rhymes and Jamie XX.
You can see the full line-up in the above video, featuring the wonderful work of Kate Moross, who has previously done animation for Alpines, Simian Mobile Disco and Jessie Ware.
Also playing the festival - which can hold over 70,000 people per day - are the Grammy award-nominated Wolf Alice, Grime MC Stormzy and indie favourites Circa Waves.
Music festivals guide 2016
Music festivals guide 2016
Where: Bansko Ski Resort, Bulgaria When: 12-17 March Price: From £175 Line Up: Âme, Goldie, Nina Kraviz, John Talabot, Lady Leshurr, Craig Charles
2/20 Live At Leeds
Where: Leeds, UK When: 30 April Price: £32.50 Line Up: Jess Glynne, Circa Waves, Mystery Jets, Band of Skulls, We Are Scientists
3/20 Primavera Sound
Where: Barcelona, Spain When: 1-5 June Price: €175 Line Up: Radiohead, LCD Soundsystem, Sigur Rós, PJ Harvey, Tame Impala, Beach House, Suede, The Last Shadow Puppets
4/20 Best Kept Secret
Where: Hilvarenbeek, The Netherlands When: 17-19 June Price: €147.50 Line Up: Beck, Editors, Two Door Cinema Club, Beach House, Bloc Party, Caribou, Half Moon Run
Best Kept Secret Festival
Where: Worthy Farm, Somerset When: 22-26 June Price: £220 Line Up: Coldplay, Muse, Jeff Lynne’s ELO, PJ Harvey, Jess Glynne (TBC)
Where: Copenhagen, Denmark When: 25 June-2 July Price: 2,020 DKK Line Up: LCD Soundsystem, New Order, PJ Harvey, Red Hot Chili Peppers, Foals, Tame Impala, Savages, Skepta, Tenacious D
Simon Frøsig Christensen / Roskilde Festival
7/20 Hideout Festival
Where: Zrce Beach, Croatia When: 26-30 June Price: From £152.90 Line Up: The Martinez Brothers, Joris Voorn, Waze & Odyssey
8/20 Bilbao BBK
Where: Bilbao, Spain When: 7-9 July Price: From £69 Line Up: Arcade Fire, Pixies, Tame Impala, Foals, New Order, Hot Chip, Father John Misty, Years & Years, Wolf Alice
Where: Gdynia, Poland When: 29 July-2 August Price: From €130 Line Up: Bastille, Florence + the Machine, Foals, LCD Soundsystem, Red Hot Chili Peppers, The 1975, The Last Shadow Puppets, Wiz Khalifa
10/20 Electric Love
Where: Plainfeld, Austria When: 7-9 July Price: €119 Line Up: Alesso, Zedd, Tiesto, Chase & Status, Steve Aoki, Knife Party
Where: Ferropolis, Germany When: 15-17 July Price: From €136 Line Up: Two Door Cinema Club, Disclosure, Jamie xx, Sleaford Mods, Skepta, Jamie Woon
Where: Budapest, Hungary When: 10-17 August Price: From €215 Line Up: Bastille, Bloc Party, M83, Sigur Ros, Bring Me the Horizon
Where: Helsinki, Finland When: 12-14 August Price: €165 Line Up: Sia, New Order, The Last Shadow Puppets, Jamie xx, M83, Chvrches, Four Tet, Stormzy, Daughter, The Kills
Flow Festival / Jussi Hellsten
14/20 Rock En Seine
Where: Paris, France When: 26-28 August Price: From €119 Line Up: TBC
Where: Marrakech, Morocco When: 16-18 September Price: From €110 Line Up: Bicep, Derrick May, Tale of Us, Dixon, Dusky, Hunee
Where: Henham Park, Suffolk When: 14-17 July Price: £205.50 Line Up: The Maccabees, The National, New Order, John Grant, Beirut, Father John Misty, Chvrches, Grimes
Where: Robin Hill, Isle of Wight When: 8-11 September Price: £190 Line Up: The Cure, Major Lazer, Hot Chip, Fatboy Slim, Craig David, Years & Years, Wolf Alice, Tourist, Katy B
18/20 Isle of Wight
Where: Newport, Isle of Wight When: 9-12 June Price: From £186 Line Up: Queen + Adam Lambert, Stereophonics, Faithless, Iggy Pop, Adam Ant, Buzzcocks, Sigma, Jess Glynne
Where: Victoria Park, London When: 17 July Price: From £54 Line Up: Sigur Rós, Caribou, Lianne La Havas, Nathaniel Rateliff & the Night Sweats
20/20 End of the Road
Where: Larmer Tree Gardens When: 2-4 September Price: £195 Line Up: Joanna Newsom, The Shins, Animal Collective, Bat for Lashes, Teenage Fanclub, Devendra Banhart, Savages, Cat's Eyes
Jess Glynne, Years & Years and Katy B are also set to make appearances, with yet more acts to be announced.
Last year's festival saw the likes of Disclosure and Rudimental headline, as well as memorable performances from Wu Tang Clan, Everything Everything and Nas.
This is the festival's seventh year, with Snoop Dogg, Foals and Sam Smith having played in 2014.
Parklife 2016 will take place 11-12 June, with tickets available from 9am on the 11 February through the official website.