Search Engines: Serendipity The benefits of giggling
Simon Singh is an author, journalist and TV producer, specialising in science and Mathematics. His latest book is "Trick or Treatment? Alternative Medicine on Trial", co-authored with Edzard Ernst, the world’s first professor of complementary medicine.
Sunday 11 April 1999
Davy considered selling nitrous oxide, better known as laughing gas, as a cheap alternative to alcohol, but instead he simply held laughing gas parties, which were attended by such eminent figures as Samuel Taylor Coleridge and Peter Roget of Roget's Thesaurus. The idea caught on, and soon many Victorians were using laughing gas as a recreational drug.
In America, touring shows demonstrated the freakish effects of the gas on volunteers. In 1844 in Hartford, Connecticut, it was said that "some danced, some sang, others made impassioned orations, or indulged in serious arguments with imaginary opponents". Samuel Cooley was invited on to the stage to inhale the gas, but he reacted violently, fell, injured himself, and was helped back to his seat. Later, an audience member made the following observation: "Presently he [Cooley] was seen to roll up his trousers and gaze in a puzzled sort of way at an excoriated and bloody leg." Cooley had severely gashed his leg, but apparently felt no pain and was unaware of his injury until he saw the blood.
Cooley had been accompanied to the show by a dentist called Horace Wells. For Wells, the whole episode resulted in a serendipitous revelation, because he realised that the laughing gas had made Cooley impervious to pain. A few days later, Wells tested the gas on himself and had one of his own teeth extracted by a colleague. The extraction was painless, and thereafter the use of laughing gas as an anaesthetic gradually spread.
For the last 150 years, laughing gas has been used to remove pain in situations ranging from dentistry to childbirth, but it was only last year that scientists finally had a clue as to how it works. A research group at Washington University, St Louis, discovered that laughing gas targets a brain receptor known as the NMDA (N-methyl-D- aspartate) receptor, which seems to play several key roles in the central nervous system.
As a result, researchers can begin to study the effects of laughing gas in detail, examining how it interacts with the brain, looking for side effects and possible benefits. For example, the NMDA receptor has been implicated in exacerbating the death of brain neurons during head injuries. One idea is to administer laughing gas soon after a head injury, which would target and block these receptors, thereby minimising the damage to neurons. This research is still at an early stage, but further study is under way.
IF THERE was one event which showed that the sea has really changed, it was the success of the Dixons' free Internet service, Freeserve. Within a few weeks, 900,000 people signed up - around one in 50 of the adult population. At the beginning of this month, Tesco announced that holders of its loyalty card could also have Internet access for nothing. Immediately, Freeserve cut the price of its technical support phonelines to 50p a minute, halving the one cost of their service. With major High Street retailers fighting among themselves to give Internet services away, and the public signing up in droves, it looks as though the Net is now one of our mass media. Real people are getting on line.
I began to notice signs this was imminent last summer. Previously unwired journalists took to e-mail like ducks to water, and it at last became the standard communication medium within the electronic messaging systems to communicate across office networks. All it took was for these systems to be connected to the rest of the world. based industries, large and small, where it hasn't already done so. At the moment, e-mail is still a novelty in many quarters. With each Microsoft release, office workers of the world are carried another step towards total messaging, global and local. The preview copies of the Office 2000 suite come with one loud clear message: The network is everytment, e-mhing.
It was also last summer that Charles Jonscher realised how big the Net was going to be. In his book Wired Life (Bantam), he recalls overhearing two elderly couples exchanging addresses after a guided tour of a tourist quite routinely and with no comments. They had reached the stage where asking whether somebody was on the Internet was as unnecessary as asking whether they were on the far hence, you will be those people.In the meantime, we're faced with the question of how to make sense of it all. When I first started writing a digital culture column in the Sunday Review, nearly three years ago, the prevailing prejudice was that the Internet contained nothing but trivia and nastiness. By the time we changed to a graphic format, I was confident that people accepted the Net was interesting, but not so sure that they considered it to be useful. By now, the practical value of the Internet is beyond argument. The difficulty is in standing its implications is more important than eveve been shove been sment, e- mhor.
The latest myth about the Net is that it is like the High Street. The corner shops have been squeezed out by the big players, the disreputable elements have been shooed out of the pedestrian precincts, and the whole thing is set to become one vastoccess and systems to be connected to the rest of the world. a mailbox, standard into a site or a disc. If there's a worrying question for digital culture, it's whether people will continue to work for the Web's sake now that there's real money to be made.
Art Piece taken off website amid 'severe security alert'
Maisie Williams single-handedly rises to the challengeTV
Academy criticised after no non-white actors nominated
tvAn expose of hooliganism masquerading as an ideological battle
artLee Hadwin can't draw when he's awake, but by night he's an artist
Arts & Ents blogs
- 1 Paris attacks: Do not call Charlie Hebdo killers 'terrorists', BBC says
- 2 Man who held up 'hire me' sign at Waterloo station returns a year later with 'I'm hiring' sign
- 3 UK weather: Snow to fall in the coming week with sub-zero temperatures to last until early February
- 4 Saudi preacher who 'raped and tortured' his five -year-old daughter to death is released after paying 'blood money'
- 5 The enemy within: People who hear voices in their heads are being encouraged to talk back
Mr Selfridge series 3: Actress Kara Tointon says 'we're starting to see his demise'
Benedict Cumberbatch says Hollywood is better for black British actors
Sia apologises for 'Elastic Heart' music video that sees Shia LaBeouf wrestle 12-year-old Maddie Ziegler
V&A removes depiction of Prophet Mohamed from website amid 'severe security alert'
Game of Thrones season 5: IMAX releases new trailer with first look footage of Tyrion Lannister
Nigel Farage: NHS might have to be replaced by private health insurance
'We would evict Queen from Buckingham Palace and allocate her council house,' say Greens
French court convicts three over homophobic tweets, in case hailed as a 'significant victory' by LGBT rights campaigners
Greece elections: Syriza and EU on collision course after election win for left-wing party
George Galloway condemns 'racist, Islamophobic, hypocritical rag' Charlie Hebdo at freedom of speech rally
British Muslim school children suffering a backlash of abuse following Paris attacks