Serendipity: An antisocial accident

ON 13 SEPTEMBER 1848, a railroad engineer by the name of Phineas Gage was preparing for a rock blast when something suddenly went through his mind, namely a four-foot iron rod. A premature detonation had forced the rod into Gage's left cheek, through his brain, and out of the top his skull, eventually landing 100ft away. Remarkably, moments later Gage was able to "walk off, talking with composure and equanimity of the hole in his head".

However, as the weeks passed, his friends and colleagues realised that the accident had seriously affected his personality. He was described as "fitful, irreverent, indulging at times in the grossest profanity which was not previously his custom, manifesting but little deference for his fellows, impatient of restraint or advice when it conflicts with his desires".

Although the accident destroyed Gage's personal life, it resulted in a major breakthrough in the understanding of the brain. Scientists began to think of the brain as a series of modules, each one with different responsibilities. For example, the frontal lobes contain modules that control speech and motor functions, and also the modules that help people to behave rationally and interact socially. The rod had entered Gage's frontal lobes, leaving intact the bits that deal with speech and motor functions, but destroying the bits that made him sociable and rational.

Last year neuroscientists from all over the world gathered to mark the 150th anniversary of Gage's accident and to discuss his and similar cases. For example, in the early 1990s there was the case of "Elliot", who suffered from a brain tumour that pressurised and damaged his frontal lobes. After the tumour had been removed, he remained in control of all his physical faculties and scored highly on IQ tests, but he lacked social intelligence. Following years of success as a salesman, he lost his job, his wife divorced him, and a new business venture ended in bankruptcy.

The conference also discussed the various lines of research that Gage had inspired. Ann Streissguth at the University of Washington has been studying foetal alcohol syndrome, a range of conditions caused by exposure to alcohol while in the womb. The syndrome includes poor judgement and a lack of emotion, which was also true of Gage. Streissguth is currently testing the hypothesis that alcohol affects the frontal lobes in a way that is not dissimilar to the destruction caused by an iron rod.

Gage's accident created the science of behavioural biology and helped treat subsequent victims, but his own life was ruined. He could not hold down a job, he had to become a circus freak in order to survive and died at the age of 38. His skull can still be seen at the Warren Medical Museum of Harvard University.

Arts & Entertainment
TV

Arts & Entertainment
Customers browse through Vinyl Junkies record shop in Berwick Street, Soho, London
music

Arts & Entertainment
Who laughs lass: Jenny Collier on stage
ComedyCollier was once told there were "too many women" on bill
Arts & Entertainment
Ian Anderson, the leader of British rock band Jethro Tull, (right) and British guitar player Martin Barre (left) perform on stage
music

VIDEO
Have you tried new the Independent Digital Edition iPad app?
Arts & Entertainment
Don (John Hamm) and Megan (Jessica Paré) Draper are going their separate ways in the final series of ‘Mad Men’
tvReview: The suits are still sharp, but Don Draper has lost his edge
Arts & Entertainment
James Franco and Chris O'Dowd in Of Mice and Men on Broadway
theatre

Review: Of Mice and Men

Arts & Entertainment
art

By opportunistic local hoping to exhibit the work

Arts & Entertainment
Leonardo DiCaprio will star in an adaptation of Michael Punke's thriller 'The Revenant'
film

Fans will be hoping the role finally wins him an Oscar

Arts & Entertainment
Cody and Paul Walker pictured in 2003.
film

Arts & Entertainment
Down to earth: Fern Britton presents 'The Big Allotment Challenge'
TV

Arts & Entertainment
The London Mozart Players is the longest-running chamber orchestra in the UK
musicThreatened orchestra plays on, managed by its own members
Arts & Entertainment
Seeing red: James Dean with Sal Mineo in 'Rebel without a Cause'
film

Arts & Entertainment
TV
Arts & Entertainment
Heads up: Andy Scott's The Kelpies in Falkirk
art

What do gigantic horse heads tell us about Falkirk?

Arts & Entertainment
artGraffiti legend posts picture of work – but no one knows where it is
Arts & Entertainment
A close-up of Tom of Finland's new Finnish stamp
art

Finnish Postal Service praises the 'self irony and humour' of the drawings

Arts & Entertainment
Pierce Brosnan as James Bond in 2002's Die Another Day
film

The actor has confessed to his own insecurities

Life & Style
Green fingers: a plot in East London
TV

Allotments are the focus of a new reality show

Arts & Entertainment
Myleene Klass attends the Olivier awards 2014

Oliviers 2014Theatre stars arrive at Britain's most prestigious theatre awards
Arts & Entertainment
Stars of The Book of Mormon by Trey Parker and Matt Stone of South Park

Oliviers 2014Blockbuster picked up Best Musical and Best Actor in a Musical
Arts & Entertainment
Lesley Manville with her Olivier for Best Actress for her role in 'Ghosts'

Oliviers 2014Actress thanked director Richard Eyre for a stunning production
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Have you tried new the Independent Digital Edition iPad app?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    How I brokered a peace deal with Robert Mugabe: Roy Agyemang reveals the delicate diplomacy needed to get Zimbabwe’s President to sit down with the BBC

    How I brokered a peace deal with Robert Mugabe

    Roy Agyemang reveals the delicate diplomacy needed to get Zimbabwe’s President to sit down with the BBC
    Video of British Muslims dancing to Pharrell Williams's hit Happy attacked as 'sinful'

    British Muslims's Happy video attacked as 'sinful'

    The four-minute clip by Honesty Policy has had more than 300,000 hits on YouTube
    Church of England-raised Michael Williams describes the unexpected joys in learning about his family's Jewish faith

    Michael Williams: Do as I do, not as I pray

    Church of England-raised Williams describes the unexpected joys in learning about his family's Jewish faith
    A History of the First World War in 100 moments: A visit to the Front Line by the Prime Minister's wife

    A History of the First World War in 100 moments

    A visit to the Front Line by the Prime Minister's wife
    Comedian Jenny Collier: 'Sexism I experienced on stand-up circuit should be extinct'

    Jenny Collier: 'Sexism on stand-up circuit should be extinct'

    The comedian's appearance at a show on the eve of International Women's Day was cancelled because they had "too many women" on the bill
    Cannes Film Festival: Ken Loach and Mike Leigh to fight it out for the Palme d'Or

    Cannes Film Festival

    Ken Loach and Mike Leigh to fight it out for the Palme d'Or
    The concept album makes surprise top ten return with neolithic opus from Jethro Tull's Ian Anderson

    The concept album makes surprise top ten return

    Neolithic opus from Jethro Tull's Ian Anderson is unexpected success
    Lichen is the surprise new ingredient on fine-dining menus, thanks to our love of Scandinavian and Indian cuisines

    Lichen is surprise new ingredient on fine-dining menus

    Emily Jupp discovers how it can give a unique, smoky flavour to our cooking
    10 best baking books

    10 best baking books

    Planning a spot of baking this bank holiday weekend? From old favourites to new releases, here’s ten cookbooks for you
    Jury still out on Manchester City boss Manuel Pellegrini

    Jury still out on Pellegrini

    Draw with Sunderland raises questions over Manchester City manager's ability to motivate and unify his players
    Ben Stokes: 'Punching lockers isn't way forward'

    Ben Stokes: 'Punching lockers isn't way forward'

    The all-rounder has been hailed as future star after Ashes debut but incident in Caribbean added to doubts about discipline. Jon Culley meets a man looking to control his emotions
    Mark Johnston: First £1 million jackpot spurs him on

    Mark Johnston: First £1 million jackpot spurs him on

    The most prize money ever at an All-Weather race day is up for grabs at Lingfield on Friday, and the record-breaking trainer tells Jon Freeman how times have changed
    Ricky Gervais: 'People are waiting for me to fail. If you think it's awful, then just don't watch it'

    Ricky Gervais: 'People are waiting for me to fail'

    As the second series of his divisive sitcom 'Derek' hits screens, the comedian tells James Rampton why he'll never bow to the critics who habitually circle his work
    Mad Men series 7, TV review: The suits are still sharp, but Don Draper has lost his edge

    Mad Men returns for a final fling

    The suits are still sharp, but Don Draper has lost his edge
    Google finds a lift into space will never get off the ground as there is no material strong enough for a cable from Earth into orbit

    Google finds a lift into space will never get off the ground

    Technology giant’s scientists say there is no material strong enough for a cable from Earth into orbit