Charlie Sheen was fired from the TV situation comedy Two and a Half Men by Warner Bros Television following the hard-living actor's bouts of wild partying, repeated hospital stays and a bitter media campaign against his studio bosses.
The action was taken after "careful consideration" and was effective immediately, the studio said in a statement.
No decision has been made on the show's future without its star, Warner spokesman Paul McGuire said.
Sheen, 45, who has used TV, radio and social media to create a big megaphone for himself, was not silent for long.
In a text to The Associated Press, he responded by referring to his bosses with the F-word and, "They lose", followed by the word "Trolls".
Asked if he planned to sue, Sheen texted back, "Big". As for his next move, Sheen texted: "A big one."
The firing capped a rare, raging public battle between a Hollywood star and those who employ him, with Sheen claiming the right to live as he pleased - including the acknowledged use of illegal drugs, although he has said he is currently clean - as long as he showed up sober and ready to work.
Two and a Half Men, which debuted in 2003, stars Sheen as womanising bachelor Charlie Harper, who creates an ad hoc family with his neurotic brother, the divorced Alan (Jon Cryer) and Alan's son, Jake (Angus T. Jones).
The show was co-created by veteran producer Chuck Lorre, who contributes two other comedies to the top-rated CBS lineup, The Big Bang Theory and Mike & Molly. Like Men, both are produced with Warner.