Aspirin reduces effect of anti-depressants: study

Aspirin and other anti-inflammatory drugs taken for pain relief may reduce the effectiveness of anti-depressants such as Prozac, a US study suggested on Monday.

As many as one in five people are affected by major depressive disorders but about one-third of them are resistant to anti-depressant drugs, said the study published in the Proceedings of the National Academy of Sciences.

Researchers at Rockefeller University in New York examined the most widely used type of anti-depressants, selective serotonin reuptake inhibitors, or SSRIs, when taken in combination with ibuprofen, aspirin and naproxen.

Some well-known drugs included in the family of SSRIs include Prozac, Paxil, Lexapro and Zoloft.

In experiments on mice, researchers tracked brain levels of cell-signaling protein molecules called cytokines, which are boosted by SSRIs, and found they were counteracted by anti-inflammatory drugs.

Then, they analyzed data collected from the largest US study on anti-depressant use in humans, the STAR*D study of 4,000 adults taken over seven years and published in 2006.

The Rockefeller researchers found that 54 percent of patients not using pain relievers responded to anti-depressant therapy, but only 40 percent did among those using anti-inflammatory agents.

"The mechanism underlying these effects is not yet clear. Nevertheless, our results may have profound implications for patients, given the very high treatment resistance rates for depressed individuals taking SSRIs," said co-author Jennifer Warner-Schmidt.

The findings may have particular relevance to patients who are trying to manage both chronic pain and depression.

"Many elderly individuals suffering from depression also have arthritic or related diseases and as a consequence are taking both anti-depressant and anti-inflammatory medications," said co-author Paul Greengard.

"Our results suggest that physicians should carefully balance the advantages and disadvantages of continuing anti-inflammatory therapy in patients being treated with anti-depressant medications."

Previous studies have suggested that anti-inflammatories may actually boost the potency of two other but less common types of anti-depressants, known as tricyclic or noradrenergic anti-depressants.

ksh/ao

 

Life and Style
ebookNow available in paperback
ebooks
ebookA delicious collection of 50 meaty main courses
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Business Analyst - 12 Month FTC - Entry Level

    £23000 - £27000 per annum: Recruitment Genius: A Business Analyst is required ...

    Recruitment Genius: Chefs - All Levels

    £16000 - £23000 per annum: Recruitment Genius: To succeed, you will need to ha...

    Recruitment Genius: Maintenance Engineer

    £8 per hour: Recruitment Genius: This is an opportunity to join an award winni...

    Recruitment Genius: Telesales Executive & Customer Service - Call Centre Jobs!

    £7 - £9 per hour: Recruitment Genius: Are you outgoing? Do you want to work in...

    Day In a Page

    Isis in Syria: Influential tribal leaders hold secret talks with Western powers and Gulf states over possibility of mobilising against militants

    Tribal gathering

    Influential clans in Syria have held secret talks with Western powers and Gulf states over the possibility of mobilising against Isis. But they are determined not to be pitted against each other
    Gaza, a year on from Operation Protective Edge: A growing population and a compromised and depleted aquifer leaves water in scarce supply for Palestinians

    Gaza, a year on from Operation Protective Edge

    A growing population and a compromised and depleted aquifer leaves water in scarce supply for Palestinians
    Dozens of politicians, bureaucrats and businessmen linked to Indian bribery scandal die mysteriously

    Illnesses, car crashes and suicides

    Dozens of politicians, bureaucrats and businessmen linked to Indian bribery scandal die mysteriously
    10 best trays

    Get carried away with 10 best trays

    Serve with ceremony on a tray chic carrier
    Wimbledon 2015: Team Murray firing on all cylinders for SW19 title assault

    Team Murray firing on all cylinders for title assault

    Coaches Amélie Mauresmo and Jonas Bjorkman aiming to make Scot Wimbledon champion again
    Wimbledon 2015: Nick Bollettieri - Vasek Pospisil must ignore tiredness and tell himself: I'm in the quarter-final, baby!

    Nick Bollettieri's Wimbledon Files

    Vasek Pospisil must ignore tiredness and tell himself: I'm in the quarter-final, baby!
    Ashes 2015: Angus Fraser's top 10 moments from previous series'

    Angus Fraser's top 10 Ashes moments

    He played in five series against Australia and covered more as a newspaper correspondent. From Waugh to Warne and Hick to Headley, here are his highlights
    Greece debt crisis: EU 'family' needs to forgive rather than punish an impoverished state

    EU 'family' needs to forgive rather than punish an impoverished state

    An outbreak of malaria in Greece four years ago helps us understand the crisis, says Robert Fisk
    Gaza, a year on from Operation Protective Edge: The traumatised kibbutz on Israel's front line, still recovering from last summer's war with Hamas

    Gaza, a year on from Operation Protective Edge

    The traumatised kibbutz on Israel's front line, still recovering from last summer's war with Hamas
    How to survive electrical storms: What are the chances of being hit by lightning?

    Heavy weather

    What are the chances of being hit by lightning?
    World Bodypainting Festival 2015: Bizarre and brilliant photos celebrate 'the body as art'

    World Bodypainting Festival 2015

    Bizarre and brilliant photos celebrate 'the body as art'
    alt-j: A private jet, a Mercury Prize and Latitude headliners

    Don't call us nerds

    Craig Mclean meets alt-j - the math-folk act who are flying high
    How to find gold: The Californian badlands, digging out crevasses and sifting sludge

    How to find gold

    Steve Boggan finds himself in the Californian badlands, digging out crevasses and sifting sludge
    Singing accents: From Herman's Hermits and David Bowie to Alesha Dixon

    Not born in the USA

    Lay off Alesha Dixon: songs sound better in US accents, even our national anthem
    10 best balsamic vinegars

    10 best balsamic vinegars

    Drizzle it over salad, enjoy it with ciabatta, marinate vegetables, or use it to add depth to a sauce - this versatile staple is a cook's best friend