Data 'matchmaker' finds new uses for drugs
Sunday 21 August 2011
US scientists have devised a drug-disease matchmaking program that mines databases for potentially useful new treatment combinations and has turned up two so far, said a study on Wednesday.
For instance, a drug commonly used to alleviate ulcers has shown promise against lung cancer and an epilepsy medicine for halting seizures could also work against inflammatory bowel disease, the study said.
The research, led by Stanford University scientists and funded by the National Institutes of Health, is published in the journal Science Translational Medicine.
"This work is still at an early stage, but it is a promising proof of principle for a creative, fast and affordable approach to discovering new uses for drugs we already have in our therapeutic arsenal," said Rochelle Long, director of the NIH Pharmacogenomics Research Network.
The technique could also save money, since it costs about one billion dollars to develop a new drug these days, Long added.
The team used an NIH database that is available to the public, called the NIH National Center for Biotechnology Information Gene Expression Omnibus, which contains thousands of genomic studies from around the world.
The database compiles information on how gene activity changes during the course of disease and in response to drug treatment.
Narrowing down their focus to a range of 100 diseases and 164 drugs, the researchers created a program that scoured the database for "drugs and diseases whose gene expression patterns essentially cancelled each other out," said the study.
"For example, if a disease increased the activity of certain genes, the program tried to match it with one or more drugs that decreased the activity of those genes."
They found that an anti-ulcer treatment known as cimetidine was a good match for lung cancer, and a seizure drug topiramate would work against inflammatory bowel disease.
They tested cimetidine on human lung cancer cells - some in a lab dish and others that were transplanted into mice. Both approaches slowed the cancer cells' growth.
The anti-convulsant drug was administered to rats with bowel disease and was shown to reduce the associated symptoms of diarrhea, ulcers and colon damage.
More studies are needed to determine if the drugs will have the same effect in humans.
This is not the first time scientists have found that a drug has other uses. The popular drug Viagra was initially a treatment for heart problems but was discovered to help reverse erectile dysfunction.
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