Data 'matchmaker' finds new uses for drugs

US scientists have devised a drug-disease matchmaking program that mines databases for potentially useful new treatment combinations and has turned up two so far, said a study on Wednesday.

For instance, a drug commonly used to alleviate ulcers has shown promise against lung cancer and an epilepsy medicine for halting seizures could also work against inflammatory bowel disease, the study said.

The research, led by Stanford University scientists and funded by the National Institutes of Health, is published in the journal Science Translational Medicine.

"This work is still at an early stage, but it is a promising proof of principle for a creative, fast and affordable approach to discovering new uses for drugs we already have in our therapeutic arsenal," said Rochelle Long, director of the NIH Pharmacogenomics Research Network.

The technique could also save money, since it costs about one billion dollars to develop a new drug these days, Long added.

The team used an NIH database that is available to the public, called the NIH National Center for Biotechnology Information Gene Expression Omnibus, which contains thousands of genomic studies from around the world.

The database compiles information on how gene activity changes during the course of disease and in response to drug treatment.

Narrowing down their focus to a range of 100 diseases and 164 drugs, the researchers created a program that scoured the database for "drugs and diseases whose gene expression patterns essentially cancelled each other out," said the study.

"For example, if a disease increased the activity of certain genes, the program tried to match it with one or more drugs that decreased the activity of those genes."

They found that an anti-ulcer treatment known as cimetidine was a good match for lung cancer, and a seizure drug topiramate would work against inflammatory bowel disease.

They tested cimetidine on human lung cancer cells - some in a lab dish and others that were transplanted into mice. Both approaches slowed the cancer cells' growth.

The anti-convulsant drug was administered to rats with bowel disease and was shown to reduce the associated symptoms of diarrhea, ulcers and colon damage.

More studies are needed to determine if the drugs will have the same effect in humans.

This is not the first time scientists have found that a drug has other uses. The popular drug Viagra was initially a treatment for heart problems but was discovered to help reverse erectile dysfunction.

ksh/jm

 

Life and Style
ebookNow available in paperback
ebooks
ebookA delicious collection of 50 meaty main courses
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
SPONSORED FEATURES

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Sales Executive or Senior Sales Executive - B2B Exhibitions

    £18000 - £30000 per annum: Recruitment Genius: A Sales Executive or Senior Sal...

    Recruitment Genius: Head of Support Services

    £40000 - £55000 per annum: Recruitment Genius: This is an exciting opportunity...

    Recruitment Genius: Warehouse Team Leader

    £22000 per annum: Recruitment Genius: This industry leading company produces h...

    Recruitment Genius: Business Development Manager / Sales - OTE £40,000

    £20000 - £40000 per annum: Recruitment Genius: This IT provider for the educat...

    Day In a Page

    The Silk Roads that trace civilisation: Long before the West rose to power, Asian pathways were connecting peoples and places

    The Silk Roads that trace civilisation

    Long before the West rose to power, Asian pathways were connecting peoples and places
    House of Lords: Outcry as donors, fixers and MPs caught up in expenses scandal are ennobled

    The honours that shame Britain

    Outcry as donors, fixers and MPs caught up in expenses scandal are ennobled
    When it comes to street harassment, we need to talk about race

    'When it comes to street harassment, we need to talk about race'

    Why are black men living the stereotypes and why are we letting them get away with it?
    International Tap Festival: Forget Fred Astaire and Ginger Rogers - this dancing is improvised, spontaneous and rhythmic

    International Tap Festival comes to the UK

    Forget Fred Astaire and Ginger Rogers - this dancing is improvised, spontaneous and rhythmic
    War with Isis: Is Turkey's buffer zone in Syria a matter of self-defence – or just anti-Kurd?

    Turkey's buffer zone in Syria: self-defence – or just anti-Kurd?

    Ankara accused of exacerbating racial division by allowing Turkmen minority to cross the border
    Doris Lessing: Acclaimed novelist was kept under MI5 observation for 18 years, newly released papers show

    'A subversive brothel keeper and Communist'

    Acclaimed novelist Doris Lessing was kept under MI5 observation for 18 years, newly released papers show
    Big Blue Live: BBC's Springwatch offshoot swaps back gardens for California's Monterey Bay

    BBC heads to the Californian coast

    The Big Blue Live crew is preparing for the first of three episodes on Sunday night, filming from boats, planes and an aquarium studio
    Austin Bidwell: The Victorian fraudster who shook the Bank of England with the most daring forgery the world had known

    Victorian fraudster who shook the Bank of England

    Conman Austin Bidwell. was a heartless cad who carried out the most daring forgery the world had known
    Car hacking scandal: Security designed to stop thieves hot-wiring almost every modern motor has been cracked

    Car hacking scandal

    Security designed to stop thieves hot-wiring almost every modern motor has been cracked
    10 best placemats

    Take your seat: 10 best placemats

    Protect your table and dine in style with a bold new accessory
    Ashes 2015: Alastair Cook not the only one to be caught in The Oval mindwarp

    Cook not the only one to be caught in The Oval mindwarp

    Aussie skipper Michael Clarke was lured into believing that what we witnessed at Edgbaston and Trent Bridge would continue in London, says Kevin Garside
    Can Rafael Benitez get the best out of Gareth Bale at Real Madrid?

    Can Benitez get the best out of Bale?

    Back at the club he watched as a boy, the pressure is on Benitez to find a winning blend from Real's multiple talents. As La Liga begins, Pete Jenson asks if it will be enough to stop Barcelona
    Athletics World Championships 2015: Beijing witnesses new stage in the Jessica Ennis-Hill and Katarina Johnson-Thompson heptathlon rivalry

    Beijing witnesses new stage in the Jess and Kat rivalry

    The last time the two British heptathletes competed, Ennis-Hill was on the way to Olympic gold and Johnson-Thompson was just a promising teenager. But a lot has happened in the following three years
    Jeremy Corbyn: Joining a shrewd operator desperate for power as he visits the North East

    Jeremy Corbyn interview: A shrewd operator desperate for power

    His radical anti-austerity agenda has caught the imagination of the left and politically disaffected and set a staid Labour leadership election alight
    Isis executes Palmyra antiquities chief: Defender of ancient city's past was killed for protecting its future

    Isis executes Palmyra antiquities chief

    Robert Fisk on the defender of the ancient city's past who was killed for protecting its future