Genetic test could decide if patients get heart drug: report

Genetic testing can help determine whether heart surgery patients benefit from the popular anti-platelet drug clopidogrel, which has been effective for some but carries major risks, a study published Tuesday said.

The drug is marketed under the brand name Plavix by Bristol-Meyers Squibb in the United States and Sanofi-Aventis in France.

Clopidogrel, among the most commonly prescribed medications, has been shown to reduce cardiovascular problems in patients undergoing heart procedures like balloon angioplasty or stent placement to open narrowed coronary arteries.

But scientists said there is a great degree of variation in how patients respond to the drug, which can be predicted by a genetic test which measures the presence of a particular enzyme in the blood.

The authors of a study appearing in the Journal of the American Medical Association said that analysis of existing data suggest that the pharmacologic effect of the drug varies based on variations of the gene CYP2C19.

"There is a large degree of interindividual variability in the pharmaco-dynamic response to clopidogrel," wrote the authors, researchers with the Harvard Medical School and the Brigham and Women's Medical Center.

The study in the October 27 issue of JAMA analyzed data from previously published studies on the use of clopidogrel, and found that patients who have common genetic variants of a certain gene and who also undergo a coronary stent placement have an increased risk of blood clots or other heart related complication.

"Common genetic variants in the CYP2C19 gene are associated with almost one in three patients not receiving ideal protection from ischemic events when treated with standard doses of clopidogrel for PCI" or percutaneous coronary intervention - procedures such as the heart stent placement surgery, the authors of the study concluded.

"Given how widely clopidogrel is used to treat patients with cardiovascular disease, determination of the optimal antiplatelet treatment doses or regimens for individual patients is needed to tailor therapy appropriately," they wrote.

The research compiled nine separate studies involving 9,685 patients (of whom 91.3 percent underwent PCI and 54.5 percent had an acute coronary syndrome, the authors of the study wrote.

js/sg/ksh

 

Life and Style
ebookNow available in paperback
ebooks
ebookA delicious collection of 50 meaty main courses
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
SPONSORED FEATURES

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Kitchen and Bathroom Installers

    £18000 - £20000 per annum: Recruitment Genius: This provider of designer kitch...

    Recruitment Genius: Office Manager

    Negotiable: Recruitment Genius: The infrastructure, support services and const...

    Recruitment Genius: Personal Tax Senior

    £28000 - £37000 per annum: Recruitment Genius: This is an opportunity to join ...

    Recruitment Genius: Customer and Markets Development Executive

    £22000 - £29000 per annum: Recruitment Genius: This company's mission is to ma...

    Day In a Page

    Orthorexia nervosa: How becoming obsessed with healthy eating can lead to malnutrition

    Orthorexia nervosa

    How becoming obsessed with healthy eating can lead to malnutrition
    Lady Chatterley is not obscene, says TV director

    Lady Chatterley’s Lover

    Director Jed Mercurio on why DH Lawrence's novel 'is not an obscene story'
    Farmers in tropical forests are training ants to kill off bigger pests

    Set a pest to catch a pest

    Farmers in tropical forests are training ants to kill off bigger pests
    Mexico: A culture that celebrates darkness as an essential part of life

    The dark side of Mexico

    A culture that celebrates darkness as an essential part of life
    Being sexually assaulted was not your fault, Chrissie Hynde. Don't tell other victims it was theirs

    Being sexually assaulted was not your fault, Chrissie Hynde

    Please don't tell other victims it was theirs
    A nap a day could save your life - and here's why

    A nap a day could save your life

    A midday nap is 'associated with reduced blood pressure'
    If men are so obsessed by sex, why do they clam up when confronted with the grisly realities?

    If men are so obsessed by sex...

    ...why do they clam up when confronted with the grisly realities?
    The comedy titans of Avalon on their attempt to save BBC3

    Jon Thoday and Richard Allen-Turner

    The comedy titans of Avalon on their attempt to save BBC3
    The bathing machine is back... but with a difference

    Rolling in the deep

    The bathing machine is back but with a difference
    Part-privatised tests, new age limits, driverless cars: Tories plot motoring revolution

    Conservatives plot a motoring revolution

    Draft report reveals biggest reform to regulations since driving test introduced in 1935
    The Silk Roads that trace civilisation: Long before the West rose to power, Asian pathways were connecting peoples and places

    The Silk Roads that trace civilisation

    Long before the West rose to power, Asian pathways were connecting peoples and places
    House of Lords: Outcry as donors, fixers and MPs caught up in expenses scandal are ennobled

    The honours that shame Britain

    Outcry as donors, fixers and MPs caught up in expenses scandal are ennobled
    When it comes to street harassment, we need to talk about race

    'When it comes to street harassment, we need to talk about race'

    Why are black men living the stereotypes and why are we letting them get away with it?
    International Tap Festival: Forget Fred Astaire and Ginger Rogers - this dancing is improvised, spontaneous and rhythmic

    International Tap Festival comes to the UK

    Forget Fred Astaire and Ginger Rogers - this dancing is improvised, spontaneous and rhythmic
    War with Isis: Is Turkey's buffer zone in Syria a matter of self-defence – or just anti-Kurd?

    Turkey's buffer zone in Syria: self-defence – or just anti-Kurd?

    Ankara accused of exacerbating racial division by allowing Turkmen minority to cross the border