Alzheimer's drug hailed as a 'major' development

The first of a new class of treatments for Alzheimer's disease has been shown to be more than twice as effective as existing drugs in slowing progression of the condition, scientists said yesterday.

The drug, Rember, is the latest of a group of new treatments for the degenerative disease announced in the past two weeks but one with the greatest potential, experts said.

Rember is the first drug to act on the nerve tangles discovered by Alois Alzheimer a century ago which are thought to be the cause of the disease. The early (Phase 2) trial of 321 patients showed it slowed progression by 81 per cent compared with placebos.

The Alzheimer's Society described Rember as "a major new development" and said the results were "potentially exciting" but warned larger trials were needed. The drug was developed by scientists at the University of Aberdeen working with the Singapore-based company TauRx Therapeutics – a spin off from the university.

Professor Claude Wishcik, chairman of TauRx, who presented the findings at the International Conference on Alzheimer's Disease in Chicago yesterday, said: "This is an unprecedented result in the treatment of Alzheimer's Disease. We have demonstrated for the first time that it may be possible to arrest progression by targeting the tangles."

In a separate development, scientists from Imperial College London and the University of Uppsala, Sweden, reported that a new drug, PBT2, slows the build-up of protein leading to plaques. Results of the early trial, published in The Lancet Neurology and presented to the conference, show patients who took the drug over 12 weeks had significantly improved cognitive performance.

PROMOTED VIDEO
Life and Style
ebookNow available in paperback
ebooks
ebookPart of The Independent’s new eBook series The Great Composers
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Tradewind Recruitment: PMLD Teacher

    Negotiable: Tradewind Recruitment: PMLD Teacher A specialist primary school i...

    Recruitment Genius: Online Media Sales Trainee

    £15000 - £30000 per annum: Recruitment Genius: Now our rapidly expanding and A...

    Recruitment Genius: Public House Manager / Management Couples

    £15000 - £20000 per annum: Recruitment Genius: Are you passionate about great ...

    Recruitment Genius: Production Planner

    £20000 - £30000 per annum: Recruitment Genius: This fast growing reinforcing s...

    Day In a Page

    As in 1942, Germany must show restraint over Greece

    As in 1942, Germany must show restraint over Greece

    Mussolini tried to warn his ally of the danger of bringing the country to its knees. So should we, says Patrick Cockburn
    Britain's widening poverty gap should be causing outrage at the start of the election campaign

    The short stroll that should be our walk of shame

    Courting the global elite has failed to benefit Britain, as the vast disparity in wealth on display in the capital shows
    Homeless Veterans appeal: The rise of the working poor: when having a job cannot prevent poverty

    Homeless Veterans appeal

    The rise of the working poor: when having a job cannot prevent poverty
    Prince Charles the saviour of the nation? A new book highlights concerns about how political he will be when he eventually becomes king

    Prince Charles the saviour of the nation?

    A new book highlights concerns about how political he will be when he eventually becomes king
    How books can defeat Isis: Patrick Cockburn was able to update his agenda-setting 'The Rise of Islamic State' while under attack in Baghdad

    How books can defeat Isis

    Patrick Cockburn was able to update his agenda-setting 'The Rise of Islamic State' while under attack in Baghdad
    Judith Hackitt: The myths of elf 'n' safety

    Judith Hackitt: The myths of elf 'n' safety

    She may be in charge of minimising our risks of injury, but the chair of the Health and Safety Executive still wants children to be able to hurt themselves
    The open loathing between Barack Obama and Benjamin Netanyahu just got worse

    The open loathing between Obama and Netanyahu just got worse

    The Israeli PM's relationship with the Obama has always been chilly, but going over the President's head on Iran will do him no favours, says Rupert Cornwell
    French chefs get 'le huff' as nation slips down global cuisine rankings

    French chefs get 'le huff' as nation slips down global cuisine rankings

    Fury at British best restaurants survey sees French magazine produce a rival list
    Star choreographer Matthew Bourne gives young carers a chance to perform at Sadler's Wells

    Young carers to make dance debut

    What happened when superstar choreographer Matthew Bourne encouraged 27 teenage carers to think about themselves for once?
    Design Council's 70th anniversary: Four of the most intriguing prototypes from Ones to Watch

    Design Council's 70th anniversary

    Four of the most intriguing prototypes from Ones to Watch
    Dame Harriet Walter: The actress on learning what it is to age, plastic surgery, and her unease at being honoured by the establishment

    Dame Harriet Walter interview

    The actress on learning what it is to age, plastic surgery, and her unease at being honoured by the establishment
    Art should not be a slave to the ideas driving it

    Art should not be a slave to the ideas driving it

    Critics of Tom Stoppard's new play seem to agree that cerebral can never trump character, says DJ Taylor
    Bill Granger recipes: Our chef's winter salads will make you feel energised through February

    Bill Granger's winter salads

    Salads aren't just a bit on the side, says our chef - their crunch, colour and natural goodness are perfect for a midwinter pick-me-up
    England vs Wales: Cool head George Ford ready to put out dragon fire

    George Ford: Cool head ready to put out dragon fire

    No 10’s calmness under pressure will be key for England in Cardiff
    Michael Calvin: Time for Old Firm to put aside bigotry and forge new links

    Michael Calvin's Last Word

    Time for Old Firm to put aside bigotry and forge new links