Blow for sufferers as experimental Alzheimer's drug is scrapped
Studies of one of the most anticipated experimental drugs for Alzheimer's disease have been scrapped after it failed to help patients with the condition in a high-profile clinical trial.
Pfizer Inc and Johnson & Johnson said they would discontinue all other studies of the drug bapineuzumab including two more trials and follow-up extension studies, in patients with mild-to-moderate Alzheimer's.
The result marked the second such late-stage failure announced in recent weeks and was especially disappointing as bapineuzumab had been given a better chance of success in the patients studied in the second trial. If successful, it would have been the first drug to fight the progression of the debilitating brain disease.
Attention will now turn to solanezumab, a similar drug being developed by Eli Lilly & Co that is also considered a long-shot to succeed, but will still carry fading hopes at least until test results are released later this year. Shares in all three drugs firms fell following news of the latest disappointment.
Any successful Alzheimer's treatment is likely to reap many billions of pounds in sales, and industry analysts said many investors were holding shares in the companies in case the drugs were to succeed. "We are obviously very disappointed in the outcomes of this trial. We are also saddened by the lost opportunity to provide a meaningful advance for patients afflicted with mild-to-moderate Alzheimer's disease," said Steven Romano, head of Pfizer's medicines development group.
Life & Style blogs
Other popular areas include Didsbury, Clifton in Bristol, central Cambridge and West Bridgford
Doctors are allowed to have personal beliefs, just as long as these beliefs do not interfere with th...
BBC journalist Justin Webb talks about his experiences of the advances in preventing heart attacks a...
Mariane Pearl: Al-Qa'ida killed my husband, not my hope
Meet David Karp, the 26-year-old high school dropout worth $275m after selling Tumblr to Yahoo
Game on: Xbox 720 and PS4 go head to head with Microsoft set to launch console today
Virtually Stephen Fry: Star launches (possibly) the world's most self-regarding app
The 10 Best children's activity books
- 1 'He was lucky he didn't die' - George Michael fell out of speeding car onto M1 motorway, according to eye witness
- 2 Tottenham to smash pay scale with £150,000-a-week contract in attempt to tie Gareth Bale to club
- 3 Austerity has hardened the nation's heart
- 4 Gay couple beaten in park urge MPs to moderate language on gay marriage
- 5 Why Arsène Wenger must spend to put icing on the cake and buy likes of Stevan Jovetic for Arsenal
BMF is the UK’s biggest and best loved outdoor fitness classes
Find out what The Independent's resident travel expert has to say about one of the most beautiful small cities in the world
Win anything from gadgets to five-star holidays on our competitions and offers page.
£26000 - £33000 Per Annum: The Green Recruitment Company: The Green Recruitmen...
Negotiable: Randstad Education Sheffield: We are currently recruiting newly qu...
Negotiable: Progressive Recruitment: Dear Sumadhab, A growing engineering comp...
£53000 - £58000 per annum: Randstad Education Group: Assistant Headteacher - S...