Diet 'may raise breast cancer risk'

 

Poor diet early in life may predispose women to develop breast cancer, research suggests.

A US study of young mice showed that a diet linked to obesity and harmful metabolic changes stimulated early breast growth.

It also led to abnormal tissues in the breast that may produce breast cancer.

Lead researcher Dr Russ Hovey, from the University of California at Davis, said: "The findings of this study are particularly important when we superimpose them on data showing that girls are experiencing breast development at earlier ages, coincident with a growing epidemic of childhood obesity."

The scientists fed newly weaned mice a diet containing a fatty acid called 10,12 CLA which can trigger metabolic syndrome, a condition linked to obesity, diabetes and heart disease.

The fatty acid is present in hydrogenated fats, widely used in the manufacture of biscuits, cakes and processed foods.

Giving female mice the 10,12 CLA stimulated growth of their mammary ducts. This was despite the young animals lacking the hormone oestrogen, believed to be vital to female reproductive development.

In some animals, the altered diet also resulted in the kind of abnormal cell growth that can lead to breast cancer.

The cancer link could be due to excess levels of insulin, the scientists believe.

Writing in the journal Proceedings of the National Academy of Sciences, they pointed out that postmenopausal women with raised insulin levels had an increased risk of breast cancer.

They concluded: "Our findings highlight a striking link between diet, metabolic dysregulation, and.., MG (mammary gland) growth that is independent of oestrogenic stimulation.

"These results lend support to increasing evidence suggesting a relationship between breast cancer risk and early life events that clearly include dietary components and their effects on aspects of metabolic dysregulation."

PA

PROMOTED VIDEO
Life and Style
ebooksA superb mix of recipes serving up the freshest of local produce in a delicious range of styles
Life and Style
ebooksFrom the lifespan of a slug to the distance to the Sun: answers to 500 questions from readers
Arts and Entertainment
From Mean Girls to Mamet: Lindsay Lohan
theatre
Sport
Nathaniel Clyne (No 2) drives home his side's second goal past Arsenal’s David Ospina at the Emirates
footballArsenal 1 Southampton 2: Arsène Wenger pays the price for picking reserve side in Capital One Cup
News
Mike Tyson has led an appalling and sad life, but are we not a country that gives second chances?
peopleFormer boxer 'watched over' crash victim until ambulance arrived
Arts and Entertainment
Geena Davis, founder and chair of the Geena Davis Institute on Gender in Media
tv
News
i100
Travel
travelGallery And yes, it is indoors
Life and Style
tech
Arts and Entertainment
The Tiger Who Came To Tea
booksJudith Kerr on what inspired her latest animal intruder - 'The Crocodile Under the Bed'
News
i100
Arts and Entertainment
British actor Idris Elba is also a DJ and rapper who played Ibiza last summer
film
News
Alan Bennett criticised the lack of fairness in British society encapsulated by the private school system
peopleBut he does like Stewart Lee
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Account Executive/Sales Consultant – Permanent – Hertfordshire - £16-£20k

    £16500 - £20000 Per Annum: Clearwater People Solutions Ltd: We are currently r...

    KS2 PPA Teacher needed (Mat Cover)- Worthing!

    £100 - £125 per day: Randstad Education Crawley: KS2 PPA Teacher currently nee...

    IT Systems Manager

    £40000 - £45000 per annum + pension, healthcare,25 days: Ashdown Group: An est...

    IT Application Support Engineer - Immediate Start

    £28000 per annum: Ashdown Group: IT Software Application Support Analyst - Imm...

    Day In a Page

    Syria air strikes: ‘Peace President’ Obama had to take stronger action against Isis after beheadings

    Robert Fisk on Syria air strikes

    ‘Peace President’ Obama had to take stronger action against Isis after beheadings
    Will Lindsay Lohan's West End debut be a turnaround moment for her career?

    Lindsay Lohan's West End debut

    Will this be a turnaround moment for her career?
    'The Crocodile Under the Bed': Judith Kerr's follow-up to 'The Tiger Who Came to Tea'

    The follow-up to 'The Tiger Who Came to Tea'

    Judith Kerr on what inspired her latest animal intruder - 'The Crocodile Under the Bed' - which has taken 46 years to get into print
    BBC Television Centre: A nostalgic wander through the sets, studios and ghosts of programmes past

    BBC Television Centre

    A nostalgic wander through the sets, studios and ghosts of programmes past
    Lonesome George: Custody battle in Galapagos over tortoise remains

    My George!

    Custody battle in Galapagos over tortoise remains
    10 best rucksacks for backpackers

    Pack up your troubles: 10 best rucksacks for backpackers

    Off on an intrepid trip? Experts from student trip specialists Real Gap and Quest Overseas recommend luggage for travellers on the move
    Secret politics of the weekly shop

    The politics of the weekly shop

    New app reveals political leanings of food companies
    Beam me up, Scottie!

    Beam me up, Scottie!

    Celebrity Trekkies from Alex Salmond to Barack Obama
    Beware Wet Paint: The ICA's latest ambitious exhibition

    Beware Wet Paint

    The ICA's latest ambitious exhibition
    Pink Floyd have produced some of rock's greatest ever album covers

    Pink Floyd have produced some of rock's greatest ever album covers

    Can 'The Endless River' carry on the tradition?
    Sanctuary for the suicidal

    Sanctuary for the suicidal

    One mother's story of how London charity Maytree helped her son with his depression
    A roller-coaster tale from the 'voice of a generation'

    Not That Kind of Girl:

    A roller-coaster tale from 'voice of a generation' Lena Dunham
    London is not bedlam or a cradle of vice. In fact it, as much as anywhere, deserves independence

    London is not bedlam or a cradle of vice

    In fact it, as much as anywhere, deserves independence
    Vivienne Westwood 'didn’t want' relationship with Malcolm McLaren

    Vivienne Westwood 'didn’t want' relationship with McLaren

    Designer 'felt pressured' into going out with Sex Pistols manager
    Jourdan Dunn: Model mother

    Model mother

    Jordan Dunn became one of the best-paid models in the world