Diet 'may raise breast cancer risk'
Tuesday 18 September 2012
Poor diet early in life may predispose women to develop breast cancer, research suggests.
A US study of young mice showed that a diet linked to obesity and harmful metabolic changes stimulated early breast growth.
It also led to abnormal tissues in the breast that may produce breast cancer.
Lead researcher Dr Russ Hovey, from the University of California at Davis, said: "The findings of this study are particularly important when we superimpose them on data showing that girls are experiencing breast development at earlier ages, coincident with a growing epidemic of childhood obesity."
The scientists fed newly weaned mice a diet containing a fatty acid called 10,12 CLA which can trigger metabolic syndrome, a condition linked to obesity, diabetes and heart disease.
The fatty acid is present in hydrogenated fats, widely used in the manufacture of biscuits, cakes and processed foods.
Giving female mice the 10,12 CLA stimulated growth of their mammary ducts. This was despite the young animals lacking the hormone oestrogen, believed to be vital to female reproductive development.
In some animals, the altered diet also resulted in the kind of abnormal cell growth that can lead to breast cancer.
The cancer link could be due to excess levels of insulin, the scientists believe.
Writing in the journal Proceedings of the National Academy of Sciences, they pointed out that postmenopausal women with raised insulin levels had an increased risk of breast cancer.
They concluded: "Our findings highlight a striking link between diet, metabolic dysregulation, and.., MG (mammary gland) growth that is independent of oestrogenic stimulation.
"These results lend support to increasing evidence suggesting a relationship between breast cancer risk and early life events that clearly include dietary components and their effects on aspects of metabolic dysregulation."
Life & Style blogs
Snapchat got rid of the Best Friends feature and 'stalkers' are upset
Food secrets: the good, the bad...and the faeces
Pot of gold: tasting the world’s most expensive tea
Taylor Swift’s Twitter and Instagram accounts hacked, apparently by Lizard Squad
Selfie-obsessed men may be narcissistic psychopaths, study finds
- 2 Mystery man who gave mum heart-warming note on train 'wanted to put a smile on her face'
- 5 Amal Clooney gives excellent answer to fashion question at European Court of Human Rights
Negotiable: Tradewind Recruitment: This post arises as a result of the need to...
£120 - £150 per annum: Tradewind Recruitment: I am recruiting on instruction o...
£70000 per annum: Ashdown Group: Head of Finance - Financial Controller - Fina...
£24000 - £28000 per annum + benefits: Ashdown Group: Marketing Executive - Wim...