Drug lowers cholesterol and fights hepatitis C

News in pictures
News in pictures
On Facebook
Life & Style blogs

Time for a new approach to alcohol

Ambulances were called and three drunk teenagers were brought to my care. One was so drunk we had to...

London Fashion Week countdown

London Fashion Week is nearly upon us (again) and the invites are fast piling up. Our fashion team w...

HIV orphans in Thailand prepare for the future

In Baan Gerda, a community for HIV infected or affected youngsters in Northern Thailand, a group of ...

A drug that can lower cholesterol levels and prevent the liver from being attacked by the hepatitis C virus has come a step closer following a successful trial on laboratory animals.

The drug works in an unusual way by interfering with the natural genetic mechanism in the cells of the liver that keeps cholesterol levels high and – coincidentally – allows the hepatitis virus to replicate within the organ. The study, which was carried out on African green monkeys, lowered cholesterol levels by up to 40 per cent over three months with the help of just three intra-venous injections given over five days at the start of the trial.

Each injection contained a watery solution of a short, single-stranded molecule of RNA – a close relative of DNA – which found its way to the liver and bonded with a similar type of RNA which is found within the organ's cells. This prevented the natural RNA from working normally, boosting the activity of certain genes, which lowered cholesterol and blocked the hepatitis C virus.

The study, published in Nature, was carried out by the Danish drug company Santaris. Scientists believe the findings support the idea of a new generation of drugs based on the ability to interfere with the natural functions of RNA.

Human trials of the new drug are expected to begin later this year.

Independent Comment
blog comments powered by Disqus
Career Services

Day In a Page

How an abortion divided America

How an abortion divided America

Single mother who took a pill to end her pregnancy is now fighting a landmark prosecution in a conservative state
Can you master a language in a weekend?

Can you master a language in a weekend?

Ed Cooke insists he can use his techniques as a memory expert to help novices learn even the hardest tongues.
The 10 best heaters

The 10 best heaters

From the DeLonghi Retro Fan Heater to the Dimplex MicroFire
Coming soon to a shelf near you: The publishing industry has gone mad for film-style trailers

Coming soon to a shelf near you

The publishing industry has gone mad for film-style trailers
Mad, bad and delightful to know: How Lord Byron became a cultural superstar

How Lord Byron became a cultural superstar

As the poet takes centre stage in the West End, Boyd Tonkin looks into the life of the outspoken champion of the poor
Did they all live happily ever after? That's up to you...

Did they all live happily ever after? That's up to you...

New digital novel will overturn centuries of literary tradition by allowing readers to choose how they would like story to end
How to look good for less – Primark in copycat row

How to look good for less – Primark in copycat row

With London Fashion Week starting tomorrow, designers are closeted in studios putting finishing touches to their collections
James Lawton: Arsène and Arsenal are living in the past

James Lawton

Arsène and Arsenal are living in the past
How Docherty's resurgent Reds beat Dutch greats

How Docherty's resurgent Reds beat Dutch greats

United have met Ajax only once before in Europe, in 1976. The key performers recall an electric occasion
Civil war at Ajax

Civil war at Ajax

A rift between two club legends has torn the Dutch giants apart
Lewis Moody: For an idea of where England are headed, look at Wales now

Lewis Moody column

For an idea of where England are headed, look at Wales now
Geoff Toovey: Little gem with huge incentive to become king of the world

Geoff Toovey interview

Little gem with huge incentive to become king of the world
Picture preview: Portrait of London

Portrait of London

Picture preview
No secularism please, we're British

No secularism please, we're British

Arguments about the role of religion in national life have recently acquired a new urgency
Harold Tillman: 'Chinese tourists can save the high street – if we let them'

Harold Tillman interview

'Chinese tourists can save the high street – if we let them'