First ever transplant of organ grown in laboratory
Friday 08 July 2011
A 36-year-old man is recovering after surgeons implanted the world's first wholly lab-grown organ into his body.
The synthetic trachea, or windpipe, was created by seeding the patient's own stem cells on to an artificial "scaffold". British scientists helped design and build the structure, an exact replica of the man's original windpipe.
Windpipes have been grown from stem cells before, but only using the collagen "skeletons" of donated tracheas. Using an entirely synthetic scaffold means patients do not have to wait for a suitable donor organ.
This is especially important for children, for whom donor tracheas are much more difficult to find.
The patient, an African student living in Iceland, had been suffering from life-threatening tracheal cancer.
Spanish regenerative medicine pioneer, Professor Paolo Macchiarini, led the operation at Karolinska University Hospital in Sweden. In 2008 he carried out the world's first tissue-engineered tracheal transplant on a 30-year-old Spanish woman, Claudia Costillo.
Professor Alexander Seifalian, from University College London, worked with Professor Macchiarini to produce the synthetic trachea scaffold. He said: "This is the first time that a wholly tissue-engineered synthetic windpipe has been made and successfully transplanted, making it an important milestone for regenerative medicine."
The Y-shaped structure was made from a plastic-like "nanocomposite" polymer material consisting of microscopic building blocks. The material had previously been developed and patented by Prof Seifalian.
To guide the process, CT (computerised tomography) scan images were obtained of the patient's damaged trachea. These were used to produce a glass mould for the nanocomposite structure.
The scaffold was taken to Sweden, where it was "seeded" with stem cells from the patient's own body. The prepared trachea was then placed in a "bioreactor", a device providing the right environment for growth.
After just two days the stem cells had grown into tracheal cells ready for transplantation.
Since the organ was built from cells originating from the patient, there was no risk of it being rejected by his immune system.
Prof Seifalian said: "Professor Macchiarini has previously performed successful transplants of tissue engineered tracheas, but on those occasions the tracheas used were taken from organ donors and then reseeded with the patient's own stem cells.
"What makes this procedure different is it's the first time that a wholly tissue-engineered synthetic windpipe has been made and successfully transplanted, making it an important milestone for regenerative medicine. We expect there to be many more exciting applications for the novel polymers we have developed."
The patient is said to be doing well and is due to be discharged from hospital tomorrow.
Life & Style blogs
Looking past the search results: Google 2.0 will 'build airports and cities' says report
Jennifer Lawrence nude pictures leaked: Reddit removes 'The Fappening' board dedicated to sharing naked pictures of celebrities
iPhone 'Wave': iOS 8 hoax claims you can charge your iPhone in the microwave - you can't
A bottle of wine a day is not bad for you and abstaining is worse than drinking, scientist claims
iOS 8: how to free up memory on your iPhone or iPad to install the update
- 1 Scottish referendum: So how about the English now being given a chance to split from England?
- 2 Stamford Hill council removes 'unacceptable' posters telling women which side of the road to walk down
- 3 Kim Kardashian 'naked pictures' leaked on 4chan weeks after Jennifer Lawrence 'The Fappening' scandal
- 4 Matthew Miller: American sentenced to hard labour in North Korea 'wanted to be Snowden II'
- 5 Iranian blogger found guilty of insulting Prophet Mohammad on Facebook sentenced to death
Unpaid Voluntary Position : Reach Volunteering: Volunteer your expertise as Tr...
£68 - £73 per day + Competitive rates of pay based on experience: Randstad Edu...
£69 - £73 per day + Competitive London rates of pay: Randstad Education Group:...
£117 - £157 per day + Competitive London rates: Randstad Education Group: * Pr...