HRT can increase advanced breast cancer risk, says study

Hormone replacement therapy can increase the risk of more advanced, potentially deadly breast cancer, a study has shown.







Death rates from the disease were found to double in a group of women who underwent HRT for an average 5.6 years.



A link between HRT and breast cancer in post-menopausal women is well known, and was demonstrated by a large American study called the Women's Health Initiative (WHI).



Now new findings from the WHI show that use of oestrogen plus progestin hormone therapy increases the incidence of more advanced forms of breast cancer.



It is also associated with a higher risk of deaths attributed to the disease.



Women taking part in the study were either given combination HRT or a dummy "placebo" pill.



Almost 13,000 women consented to having their condition monitored for an extended 11-year period after treatment.



Invasive breast cancer occurred in 385 women who received hormone treatment compared with 293 who did not.



A significantly larger percentage of women in the HRT group had breast cancers that had spread to the lymph glands.



There were 25 deaths from breast cancer among the HRT group and 12 among the placebo group. At a population level, this was the equivalent of 2.6 against 1.3 deaths per 10,000 women per year.



The findings were reported in the latest issue of the Journal of the American Medical Association.



Rowan Chlebowski, from the Los Angeles Biomedical Research Institute, and colleagues wrote: "With some exceptions, the preponderance of observational studies have associated combined hormone therapy use with an increase in breast cancers that have favourable characteristics, lower stage, and longer survival compared with breast cancers diagnosed in non-users of hormone therapy.



"However, in the WHI randomised trial, combined hormone therapy increased breast cancer risk and interfered with breast cancer detection, leading to cancers being diagnosed at more advanced stages.



"Now, with longer follow-up results available, there remains a cumulative, statistically significant increase in breast cancers in the combined hormone therapy group, and the cancers more commonly had lymph node involvement. The observed adverse influence on breast cancer mortality of combined hormone therapy can reasonably be explained by the influence on breast cancer incidence and stage."

Life and Style
ebookNow available in paperback
ebooks
ebookA delicious collection of 50 meaty main courses
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Customer Accounts Executive

    £14000 - £18000 per annum: Recruitment Genius: This is an opportunity for the ...

    Recruitment Genius: Team Administrator / Secretary - South East

    £14000 - £17000 per annum: Recruitment Genius: Full time Administrator/Secreta...

    Recruitment Genius: Parts Advisor

    £16500 - £18500 per annum: Recruitment Genius: One of the leading Mercedes-Ben...

    Recruitment Genius: Software Developer

    £27500 - £35000 per annum: Recruitment Genius: This is an exciting opportunity...

    Day In a Page

    Fifa corruption: The 161-page dossier that exposes the organisation's dark heart

    The 161-page dossier that exposes Fifa's dark heart

    How did a group of corrupt officials turn football’s governing body into what was, in essence, a criminal enterprise? Chris Green and David Connett reveal all
    Mediterranean migrant crisis: 'If Europe thinks bombing boats will stop smuggling, it will not. We will defend ourselves,' says Tripoli PM

    Exclusive interview with Tripoli PM Khalifa al-Ghweil

    'If Europe thinks bombing boats will stop smuggling, it will not. We will defend ourselves'
    Raymond Chandler's Los Angeles: How the author foretold the Californian water crisis

    Raymond Chandler's Los Angeles

    How the author foretold the Californian water crisis
    Chinese artist who posted funny image of President Xi Jinping facing five years in prison as authorities crackdown on dissent in the arts

    Art attack

    Chinese artist who posted funny image of President Xi Jinping facing five years in prison
    Marc Jacobs is putting Cher in the limelight as the face of his latest campaign

    Cher is the new face of Marc Jacobs

    Alexander Fury explains why designers are turning to august stars to front their lines
    Parents of six-year-old who beat leukaemia plan to climb Ben Nevis for cancer charity

    'I'm climbing Ben Nevis for my daughter'

    Karen Attwood's young daughter Yasmin beat cancer. Now her family is about to take on a new challenge - scaling Ben Nevis to help other children
    10 best wedding gift ideas

    It's that time of year again... 10 best wedding gift ideas

    Forget that fancy toaster, we've gone off-list to find memorable gifts that will last a lifetime
    Paul Scholes column: With the Premier League over for another year, here are my end of season awards

    Paul Scholes column

    With the Premier League over for another year, here are my end of season awards
    Heysel disaster 30th anniversary: Liverpool have seen too much tragedy to forget fateful day in Belgium

    Liverpool have seen too much tragedy to forget Heysel

    Thirty years ago, 39 fans waiting to watch a European Cup final died as a result of a fatal cocktail of circumstances. Ian Herbert looks at how a club dealt with this tragedy
    Amir Khan vs Chris Algieri: Khan’s audition for Floyd Mayweather may turn into a no-win situation, says Frank Warren

    Khan’s audition for Mayweather may turn into a no-win situation

    The Bolton fighter could be damned if he dazzles and damned if he doesn’t against Algieri, the man last seen being decked six times by Pacquiao, says Frank Warren
    Blundering Tony Blair quits as Middle East peace envoy – only Israel will miss him

    Blundering Blair quits as Middle East peace envoy – only Israel will miss him

    For Arabs – and for Britons who lost their loved ones in his shambolic war in Iraq – his appointment was an insult, says Robert Fisk
    Fifa corruption arrests: All hail the Feds for riding to football's rescue

    Fifa corruption arrests

    All hail the Feds for riding to football's rescue, says Ian Herbert
    Isis in Syria: The Kurdish enclave still resisting the tyranny of President Assad and militant fighters

    The Kurdish enclave still resisting the tyranny of Assad and Isis

    In Syrian Kurdish cantons along the Turkish border, the progressive aims of the 2011 uprising are being enacted despite the war. Patrick Cockburn returns to Amuda
    How I survived Cambodia's Killing Fields: Acclaimed surgeon SreyRam Kuy celebrates her mother's determination to escape the US

    How I survived Cambodia's Killing Fields

    Acclaimed surgeon SreyRam Kuy celebrates her mother's determination to escape to the US
    Stephen Mangan interview: From posh buffoon to pregnant dad, the actor has quite a range

    How Stephen Mangan got his range

    Posh buffoon, hapless writer, pregnant dad - Mangan is certainly a versatile actor