Jab effective against all flu strains 'a possibility by 2013'

A "universal" flu vaccine to protect against many strains of the virus for decades may be only three years away.

Flu viruses are notorious for their ability to mutate and become resistant to vaccines, but scientists believe they have cracked the problem of designing a "one fits all" jab using a new two-step approach to immunisation. Early safety trials of the vaccine have already started and its effectiveness could be tested in patients as early as 2013.

Working with mice, ferrets and monkeys, the US team first primed the immune system with influenza DNA. They then added a "booster" consisting of a regular flu vaccine. The prime-boost combination was effective against flu viruses of different subtypes and from different years, the researchers reported in the journal Science. Although the "priming" vaccine came from a 1999 virus, antibodies were generated that neutralised other strains. The vaccine was also effective against "bird flu".

In other experiments, the scientists measured how well the prime-boost vaccine protected mice and ferrets against deadly levels of flu virus. Three weeks after receiving the boost, 20 mice were exposed to high levels of 1934 flu virus and 80 per cent survived. When mice were given only the "prime" or "boost" elements alone, or a sham vaccine, all died. Similar results were seen in ferrets – good predictors of effectiveness in humans.

Study leader Dr Gary Nabel, from the US National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, said: "It would be similar to vaccination against such diseases as hepatitis, where we vaccinate early in life and then boost immunity through occasional, additional inoculations in adulthood. We may be able to begin efficacy trials of a broadly protective flu vaccine in three to five years."

Suggested Topics
PROMOTED VIDEO
Life and Style
ebookNow available in paperback
ebooks
ebookPart of The Independent’s new eBook series The Great Composers
Arts and Entertainment
Under the skin: Sarah Kane in May 1998
theatreThe story behind a new season of Sarah Kane plays
Arts and Entertainment
Preening: Johnny Depp in 'Mortdecai'
filmMortdecai becomes actor's fifth consecutive box office bomb
Sport
Bradford City's reward for their memorable win over Chelsea is a trip to face either Sunderland or Fulham (Getty)
football
News
Lars Andersen took up archery in his mid thirties
video
Voices
Focus E15 Mothers led a protest to highlight the lack of affordable housing in London
voicesLondon’s housing crisis amounts to an abuse of human rights, says Grace Dent
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Warehouse Operations & Logistics Manager

    £38000 - £42000 per annum: Recruitment Genius: One of the UK's best performing...

    Recruitment Genius: GeoDatabase Specialist - Hazard Modelling

    £35000 - £43000 per annum: Recruitment Genius: Our award-winning client is one...

    Recruitment Genius: Compressed Air Pipework Installation Engineer

    £15000 - £21000 per annum: Recruitment Genius: This leading provider of Atlas ...

    Recruitment Genius: Operations Coordinator - Pallet Network

    £18000 - £20000 per annum: Recruitment Genius: Opportunity to join established...

    Day In a Page

    Syria crisis: Celebrities call on David Cameron to take more refugees as one young mother tells of torture by Assad regime

    Celebrities call on David Cameron to take more Syrian refugees

    One young mother tells of torture by Assad regime
    The enemy within: People who hear voices in their heads are being encouraged to talk back – with promising results

    The enemy within

    People who hear voices in their heads are being encouraged to talk back
    'In Auschwitz you got used to anything'

    'In Auschwitz you got used to anything'

    Survivors of the Nazi concentration camp remember its horror, 70 years on
    Autumn/winter menswear 2015: The uniforms that make up modern life come to the fore

    Autumn/winter menswear 2015

    The uniforms that make up modern life come to the fore
    'I'm gay, and plan to fight military homophobia'

    'I'm gay, and plan to fight military homophobia'

    Army general planning to come out
    Iraq invasion 2003: The bloody warnings six wise men gave to Tony Blair as he prepared to launch poorly planned campaign

    What the six wise men told Tony Blair

    Months before the invasion of Iraq in 2003, experts sought to warn the PM about his plans. Here, four of them recall that day
    25 years of The Independent on Sunday: The stories, the writers and the changes over the last quarter of a century

    25 years of The Independent on Sunday

    The stories, the writers and the changes over the last quarter of a century
    Homeless Veterans appeal: 'Really caring is a dangerous emotion in this kind of work'

    Homeless Veterans appeal

    As head of The Soldiers' Charity, Martin Rutledge has to temper compassion with realism. He tells Chris Green how his Army career prepared him
    Wu-Tang Clan and The Sexual Objects offer fans a chance to own the only copies of their latest albums

    Smash hit go under the hammer

    It's nice to pick up a new record once in a while, but the purchasers of two latest releases can go a step further - by buying the only copy
    Geeks who rocked the world: Documentary looks back at origins of the computer-games industry

    The geeks who rocked the world

    A new documentary looks back at origins of the computer-games industry
    Belle & Sebastian interview: Stuart Murdoch reveals how the band is taking a new direction

    Belle & Sebastian is taking a new direction

    Twenty years ago, Belle & Sebastian was a fey indie band from Glasgow. It still is – except today, as prime mover Stuart Murdoch admits, it has a global cult following, from Hollywood to South Korea
    America: Land of the free, home of the political dynasty

    America: Land of the free, home of the political dynasty

    These days in the US things are pretty much stuck where they are, both in politics and society at large, says Rupert Cornwell
    A graphic history of US civil rights – in comic book form

    A graphic history of US civil rights – in comic book form

    A veteran of the Fifties campaigns is inspiring a new generation of activists
    Winston Churchill: the enigma of a British hero

    Winston Churchill: the enigma of a British hero

    A C Benson called him 'a horrid little fellow', George Orwell would have shot him, but what a giant he seems now, says DJ Taylor
    Growing mussels: Precious freshwater shellfish are thriving in a unique green project

    Growing mussels

    Precious freshwater shellfish are thriving in a unique green project