Low-calorie diet 'could stop spread of breast cancer'

 

A low-calorie diet may reduce the chances of breast cancer spreading to other parts of the body, a new study has shown.

Scientists have discovered that calorie restriction, whereby food intake is decreased by a certain percentage, could prevent triple negative breast cancers – known as TNBC and one of the most aggressive forms of cancer, as well as the least responsive to standard treatment – from spreading to other organs by strengthening the tissue surrounding the tumour.

The study, which was conducted by the department of radiation oncology at Thomas Jefferson University in Philadelphia, and was published in Breast Cancer Research and Treatment, involved feeding one group of mice a third less than another group. The results showed that TNBC was less likely to spread to new sites in the body when the mice had a restricted diet.

“The diet turned on an epigenetic program that protected the mice from metastatic disease,” said Nicole Simone, associate professor at Thomas Jefferson University.

According to the study, microbes found to increase TNBC were decreased the most when mice were treated with both radiation and calorie restriction.

This decrease, in turn, increased the production of proteins involved in strengthening the tissue surrounding the tumour.

Dr Simone says it is important to look at metabolism when treating women with cancer. Recent studies have shown that weight gain makes standard treatments for breast cancer less effective, and those who gain weight during treatment have worse cancer outcomes.

However, patients with the disease are often treated with methods such as hormonal therapy to block tumour growth and steroids to counteract the side effects of chemotherapy, both of which can alter patients’ metabolism and lead to weight gain.

The study will give researchers a molecular target for diagnosing cancers that are more likely to metastasize, and could, potentially, help develop a new drug to treat the cancers.

Life and Style
ebookNow available in paperback
ebooks
ebookA delicious collection of 50 meaty main courses
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Web Developer - Junior / Mid Weight

    £15000 - £25000 per annum: Recruitment Genius: To support their continued grow...

    Recruitment Genius: Marketing Data Specialist

    £22000 - £25000 per annum: Recruitment Genius: They are the go-to company for ...

    Recruitment Genius: Search Marketing Specialist - PPC / SEO

    Negotiable: Recruitment Genius: This is an opportunity to join the UK's leadin...

    Recruitment Genius: Sales Administrator

    Negotiable: Recruitment Genius: This caravan dealership are currently recruiti...

    Day In a Page

    Greece debt crisis: What happened to democracy when it’s a case of 'Vote Yes or else'?

    'The economic collapse has happened. What is at risk now is democracy...'

    If it doesn’t work in Europe, how is it supposed to work in India or the Middle East, asks Robert Fisk
    The science of swearing: What lies behind the use of four-letter words?

    The science of swearing

    What lies behind the use of four-letter words?
    The Real Stories of Migrant Britain: Clive fled from Zimbabwe - now it won't have him back

    The Real Stories of Migrant Britain

    Clive fled from Zimbabwe - now it won’t have him back
    Africa on the menu: Three foodie friends want to popularise dishes from the continent

    Africa on the menu

    Three foodie friends want to popularise dishes from the hot new continent
    Donna Karan is stepping down after 30 years - so who will fill the DKNY creator's boots?

    Who will fill Donna Karan's boots?

    The designer is stepping down as Chief Designer of DKNY after 30 years. Alexander Fury looks back at the career of 'America's Chanel'
    10 best statement lightbulbs

    10 best statement lightbulbs

    Dare to bare with some out-of-the-ordinary illumination
    Wimbledon 2015: Heather Watson - 'I had Serena's poster on my wall – now I'm playing her'

    Heather Watson: 'I had Serena's poster on my wall – now I'm playing her'

    Briton pumped up for dream meeting with world No 1
    Wimbledon 2015: Nick Bollettieri - It's time for big John Isner to produce the goods to go with his thumping serve

    Nick Bollettieri's Wimbledon Files

    It's time for big John Isner to produce the goods to go with his thumping serve
    Dustin Brown: Who is the tennis player who knocked Rafael Nadal out of Wimbeldon 2015?

    Dustin Brown

    Who is the German player that knocked Nadal out of Wimbeldon 2015?
    Ashes 2015: Damien Martyn - 'England are fired up again, just like in 2005...'

    Damien Martyn: 'England are fired up again, just like in 2005...'

    Australian veteran of that Ashes series, believes the hosts' may become unstoppable if they win the first Test
    Tour de France 2015: Twins Simon and Adam Yates have a mountain to climb during Tour of duty

    Twins have a mountain to climb during Tour of duty

    Yates brothers will target the steepest sections in bid to win a stage in France
    John Palmer: 'Goldfinger' of British crime was murdered, say police

    Murder of the Brink’s-MAT mastermind

    'Goldfinger' of British crime's life ended in a blaze of bullets, say police
    Forget little green men - aliens will look like humans, says Cambridge University evolution expert

    Forget little green men

    Leading evolutionary biologist says aliens will look like humans
    The Real Stories of Migrant Britain: An Algerian scientist adjusts to life working in a kebab shop

    The Real Stories of Migrant Britain

    An Algerian scientist struggles to adjust to her new life working in a Scottish kebab shop
    Bodyworlds museum: Dr Gunther von Hagens has battled legal threats, Parkinson's disease, and the threat of bankruptcy

    Dying dream of Doctor Death

    Dr Gunther von Hagens has battled legal threats, Parkinson's disease, and the threat of bankruptcy