The appendix does have a use - re-booting the gut
Monday 08 October 2007
For generations medical orthodoxy has maintained that the appendix is useless, warranting attention only for its tendency to become painfully inflamed and requiring swift removal. But now the reputation of this cul-de-sac in the human gut has been rehabilitated by a theory from a team of immunologists .
The US scientists found that the appendix acted as a "good safe house" for bacteria essential for healthy digestion, in effect re-booting the digestive system after the host has contracted diseases such as amoebic dysentery or cholera, which kill off helpful germs and purge the gut.
This function has been made obsolete by modern, industrialised society; populations are now so dense that people pick up essential bacteria from each other, allowing gut organisms to regrow without help from the appendix, the researchers said.
But in earlier centuries, when vast tracts of land were more sparsely populated and whole regions could be wiped out by an epidemic of cholera, the appendix provided survivors with a vital individual stockpile of suitable bacteria.
"The function of the appendix seems related to the massive amount of bacteria that populates the human digestive system," said Bill Parker, a professor of surgery and one of the scientists responsible for establishing its status as a useful organ. "The location of the appendix, just below the normal one-way flow of food and germs in the large intestine, helps support the theory."
Other studies had shown that, in less-developed countries where the appendix may still be useful, the rate of appendicitis was lower than in the US, he said.
The theory, developed by a team from Duke University Medical School, North Carolina, and published in the Journal of Theoretical Biology, has sent ripples through the scientific community. It "seems by far the most likely" explanation for the function of the appendix and "makes evolutionary sense", said Douglas Theobald, a professor of biochemistry at Brandeis University in Boston.
"I'll bet we'll eventually find the same sort of thing with the tonsils," said Gary Huffnagle, a professor of internal medicine and microbiology at the University of Michigan.
The appendix is a worm-like tube between two and four inches long protruding from the start of the large intestine. Doctors routinely remove it should it become infected and inflamed – a burst appendix can cause peritonitis, which can kill.
In the UK, one in six people will have their appendix out at some point in their lives, although appendicitis is most common between the ages of eight and 14. NHS surgeons perform about 39,000 appendectomies a year.
And other 'spare parts'
* Male nipples
Men have nipples and mammary tissue which can be stimulated to produce milk. They can also get breast cancer.
* Wisdom teeth
Early humans had an extra row of molars to help with the vast quantity of vegetation they had to chew .
* Coccyx
The remains of a tail lost long before man began to walk upright six million years ago.
* Spare ribs
Humans have 12 ribs but about eight per cent of people have an extra pair, as do chimps and gorillas.
Life & Style blogs
Wandsworth tops aspiring young professionals hotspot list
Other popular areas include Didsbury, Clifton in Bristol, central Cambridge and West Bridgford
Christian GPs and the morning after pill: Much needed clarification
Doctors are allowed to have personal beliefs, just as long as these beliefs do not interfere with th...
-
The 10 Best Scotch Whiskies
-
Meet David Karp, the 26-year-old high school dropout worth $275m after selling Tumblr to Yahoo
-
Game on: Xbox 720 and PS4 go head to head with Microsoft set to launch console today
-
Mothers' diets may harm IQs in two-thirds of babies
-
Xbox ONE: 'The ultimate all-in-one home entertainment system': Microsoft finally unveils its latest console
- 1 Gay couple beaten in park urge MPs to moderate language on gay marriage
- 2 After woman sells virginity for $780,000, here are the results of our prostitution survey
- 3 Exclusive: Championship clubs set to push for safe-standing trials
- 4 China agrees to impose carbon targets by 2016
- 5 Far-right French historian, 78-year-old Dominique Venner, commits suicide in Notre Dame in protest against gay marriage
Get your summer started with British Military Fitness
BMF is the UK’s biggest and best loved outdoor fitness classes
Visit York
Find out what The Independent's resident travel expert has to say about one of the most beautiful small cities in the world
Enter the latest Independent competitions
Win anything from gadgets to five-star holidays on our competitions and offers page.
Business videos from commercial thought leaders
Watch the best in the business world give their insights into the world of business.
How to say ‘I’m a sellout’
Why clubs are keen to take a stand




Comments