The pill that lets dieters eat what they like

A pill which may "lock in" the benefits of dieting, allowing dieters to return to normal eating without putting on weight, has been discovered by scientists.

The inventors also claim that the pill, a dietary supplement called alpha-lipoic acid and widely sold in health food shops, also slows ageing, which is a known effect of low-calorie diets.

But the finding has triggered a dispute between two of the scientists who carried out the research, conducted in rats, over whether it can be applied to humans.

Malcolm Goyns, director of Immorgene Concepts, a scientific research company in Stockton-on-Tees, who led the research, said he was sufficiently convinced to follow the approach himself.

Evidence from the tropical Okinawan islands in Japan's extreme south-west, which has the highest proportion of centenarians in the world, demonstrated the life-prolonging effects of calorie restriction, he said.

Their traditional diet is high in vegetables and fish and low in fat, but they also have a cultural habit known as hara hachi bu – or "eat until you are 80 per cent full".

This is based on the notion that it takes the stomach's stretch receptors 20 minutes to tell the brain how full it really is, preventing overeating – and Okinawans are among the leanest and fittest people in Japan as a result.

Dr Goyns said: "While calorie restriction diets are followed as a matter of course in communities like Okinawa, the diet can be difficult to follow for most people. Our discovery indicates that by following a calorie restriction diet for six months and then taking alpha-lipoic acid while eating normally, the same life extension effects will be experienced."

He added: "Simply adding the supplement to the diet has no effect. It seems that alpha-lipoic acid fools the body into behaving as if it was still on whatever diet it was following before the supplement was added. We found there was an anti-obesity effect as well. Although weight does rise when you come off the restricted diet, if you take alpha-lipoic acid, even though you are eating normally again you still have a reduced weight."

The study, published in Mechanisms of Ageing and Development, was carried out by Dr Goyns with colleagues from the University of Liverpool. The researchers investigated the effect of alpha-lipoic acid when given to rats on normal and low calorie diets.

Experiments have shown that curbing the amount of food rats eat can extend their lives by 25 to 40 per cent. However, anti-ageing benefits are lost when the rats return to a normal diet. In the study, researchers found the benefits of the low calorie diet were extended by giving the rats the supplement when they returned to normal eating.

Brian Merry of the School of Biological Sciences at the University of Liverpool, who carried out the study, said: "If you put the animals on to a restricted diet they would normally go on to an extended survival trajectory. When they were switched to a normal diet, this compound seemed to lock them into the benefits of their pre-existing diet."

"It is an unusual and interesting finding and it needs repeating in further research. That was as far as I was prepared to go, but Malcolm [Goyns] wanted to apply it to humans. I said I didn't agree with his interpretation and we had to wait for further studies."

He added: "People have been buying this stuff and taking it for years as a dietary supplement. I don't think anyone knows what its effect is. There have only been two studies in rats and mice [before our study].

"It is also sometimes used in stroke patients to treat re-perfusion injury. What happens as the blood supply is restored after a stroke is oxidative damage to the cells. Alpha-lipoic acid is an antioxidant and can help reduce the damage. It is also used to treat diabetics and oxidative damage to the liver in people who have eaten poisoned mushrooms."

Alpha-lipoic acid is sold as an anti-oxidant supplement and is also used in the treatment of certain conditions including stroke and liver damage.

Suggested Topics
Arts & Entertainment
Madonna in her music video for 'Like A Virgin'
music... and other misheard song lyrics
Sport
Steven Gerrard had to be talked into adopting a deeper role by his manager, Brendan Rodgers
sportThe city’s fight for justice after Hillsborough is embodied in Steven Gerrard, who's poised to lead his club to a remarkable triumph
News
Much of the colleges’ land is off-limits to locals in Cambridge, with tight security
educationAnd has the Cambridge I knew turned its back on me?
News
Waitrose will be bringing in more manned tills
newsOverheard in Waitrose: documenting the chatter in 'Britain's poshest supermarket'
VIDEO
News
The energy drink MosKa was banned for containing a heavy dose of the popular erectile dysfunction Levitra
news
Environment
People are buying increasing numbers of plants such as lavender to aid the insects
environmentGardeners rally round the endangered bumblebee
Sport
Australia's Dylan Tombides competes for the ball with Adal Matar of Kuwait during the AFC U-22 Championship Group C match in January
sportDylan Tombides was diagnosed with testicular cancer in 2011
Arts & Entertainment
Customers browse through Vinyl Junkies record shop in Berwick Street, Soho, London
musicBest exclusives coming to an independent record shop near you this Record Store Day
News
Ida Beate Loken has been living at the foot of a mountain since May
newsNorwegian gives up home comforts for a cave
Extras
indybest10 best gardening gloves
Arts & Entertainment
tvIt might all be getting a bit much, but this is still the some of the finest TV ever made, says Grace Dent
Arts & Entertainment
Comedian Lenny Henry is calling for more regulation to support ethnic actors on TV
tvActor and comedian leads campaign against 'lack of diversity' in British television
News
Posted at the end of March, this tweeted photo was a week off the end of their Broadway shows
people
News
peopleStar to remain in hospital for up to 27 days to get over allergic reaction
Arts & Entertainment
The Honesty Policy is a group of anonymous Muslims who believe that the community needs a space to express itself without shame or judgement
music
News
Who makes you happy?
happy listSend your nominations now for the Independent on Sunday Happy List
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Have you tried new the Independent Digital Edition iPad app?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Apprentice IT Technician

    £150.00 per week: QA Apprenticeships: This company is a company that specializ...

    1st Line Technical Service Desk Analyst IT Apprentice

    £153.75 per week: QA Apprenticeships: This company is an innovative outsourcin...

    1st Line Helpdesk Engineer Apprentice

    £150.00 per week: QA Apprenticeships: This company has been providing on site ...

    Sales Associate Apprentice

    £150.00 per week: QA Apprenticeships: We've been supplying best of breed peopl...

    Day In a Page

    How I brokered a peace deal with Robert Mugabe: Roy Agyemang reveals the delicate diplomacy needed to get Zimbabwe’s President to sit down with the BBC

    How I brokered a peace deal with Robert Mugabe

    Roy Agyemang reveals the delicate diplomacy needed to get Zimbabwe’s President to sit down with the BBC
    Video of British Muslims dancing to Pharrell Williams's hit Happy attacked as 'sinful'

    British Muslims's Happy video attacked as 'sinful'

    The four-minute clip by Honesty Policy has had more than 300,000 hits on YouTube
    Church of England-raised Michael Williams describes the unexpected joys in learning about his family's Jewish faith

    Michael Williams: Do as I do, not as I pray

    Church of England-raised Williams describes the unexpected joys in learning about his family's Jewish faith
    A History of the First World War in 100 moments: A visit to the Front Line by the Prime Minister's wife

    A History of the First World War in 100 moments

    A visit to the Front Line by the Prime Minister's wife
    Comedian Jenny Collier: 'Sexism I experienced on stand-up circuit should be extinct'

    Jenny Collier: 'Sexism on stand-up circuit should be extinct'

    The comedian's appearance at a show on the eve of International Women's Day was cancelled because they had "too many women" on the bill
    Cannes Film Festival: Ken Loach and Mike Leigh to fight it out for the Palme d'Or

    Cannes Film Festival

    Ken Loach and Mike Leigh to fight it out for the Palme d'Or
    The concept album makes surprise top ten return with neolithic opus from Jethro Tull's Ian Anderson

    The concept album makes surprise top ten return

    Neolithic opus from Jethro Tull's Ian Anderson is unexpected success
    Lichen is the surprise new ingredient on fine-dining menus, thanks to our love of Scandinavian and Indian cuisines

    Lichen is surprise new ingredient on fine-dining menus

    Emily Jupp discovers how it can give a unique, smoky flavour to our cooking
    10 best baking books

    10 best baking books

    Planning a spot of baking this bank holiday weekend? From old favourites to new releases, here’s ten cookbooks for you
    Jury still out on Manchester City boss Manuel Pellegrini

    Jury still out on Pellegrini

    Draw with Sunderland raises questions over Manchester City manager's ability to motivate and unify his players
    Ben Stokes: 'Punching lockers isn't way forward'

    Ben Stokes: 'Punching lockers isn't way forward'

    The all-rounder has been hailed as future star after Ashes debut but incident in Caribbean added to doubts about discipline. Jon Culley meets a man looking to control his emotions
    Mark Johnston: First £1 million jackpot spurs him on

    Mark Johnston: First £1 million jackpot spurs him on

    The most prize money ever at an All-Weather race day is up for grabs at Lingfield on Friday, and the record-breaking trainer tells Jon Freeman how times have changed
    Ricky Gervais: 'People are waiting for me to fail. If you think it's awful, then just don't watch it'

    Ricky Gervais: 'People are waiting for me to fail'

    As the second series of his divisive sitcom 'Derek' hits screens, the comedian tells James Rampton why he'll never bow to the critics who habitually circle his work
    Mad Men series 7, TV review: The suits are still sharp, but Don Draper has lost his edge

    Mad Men returns for a final fling

    The suits are still sharp, but Don Draper has lost his edge
    Google finds a lift into space will never get off the ground as there is no material strong enough for a cable from Earth into orbit

    Google finds a lift into space will never get off the ground

    Technology giant’s scientists say there is no material strong enough for a cable from Earth into orbit