Statins good for the heart and possibly infections

The same cholesterol-lowering statins taken by tens of millions worldwide to prevent cardiovascular disease may help fend off infections as well, new studies have found.

Authors of the research agreed more investigation was needed to say for sure whether statins best known for their interaction with cholesterol could be recommended as a treatment for infections such as pneumonia, sepsis or blood infections secondary to organ transplants.

The studies were presented Monday at the 50th annual ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy), the biggest global get-together on infectious disease. It is being held in Boston September 12-14.

A review of a Danish study of about 70,000 patients with pneumonia that included 7,000 who were on statins, found there was 31-percent lower mortality in the subset on statins compared to the others, said Dr. Reimar Thomsen, of Aarthus University Hospital in Denmark.

But the study did not look at a multifactorial bigger picture. For example the people on statins tended to be younger and fitter and better off than the others, Thomsen explained.

So "I believe we need to interpret these findings with great caution," he told reporters. "Therefore, randomized statin therapy trials among persons with pneumonia are badly needed to confirm or contradict the observational findings."

Dr. Nasia Safdar of the University of Wisconsin said she saw in her research there was "lower mortality" in organ transplant patients with subsequent blood infections, and who took statins.

Two weeks after transplants, a key milestone, "when we looked at mortality, we found there was a mortality benefit to statins," she said.

"The data are intriguing. It should definitely be studied further. But at this point statins cannot be recommended as standard of care ....for infection," she stressed.

Dr. Mathew Falagas, of the Alpha Institute in Athens, Greece, did a study of people with sepsis, and said be believed statins showed a "beneficial effect ... for the prevention and the treatment of patients with infection."

"But some facts limit the strength of evidence including the fact that they are very heterogenic in nature and that it's not same statins or dosages and the subject varied from healthy people to chronically ill," he cautioned.

"Statins cannot and should not be recommended for the use at the present time for prevention and treatment of infections," he stressed.

Voices
There will be a chance to bid for a rare example of the SAS Diary, collated by a former member of the regiment in the aftermath of World War II but only published – in a limited run of just 5,000 – in 2011
charity appealTime is running out to secure your favourite lot as our auction closes at 2pm today
News
File: James Woods attends the 52nd New York Film Festival at Walter Reade Theater on September 27, 2014
peopleActor was tweeting in wake of NYPD police shooting
Sport
Martin Skrtel heads in the dramatic equaliser
SPORTLiverpool vs Arsenal match report: Bandaged Martin Skrtel heads home in the 97th-minute
Arts and Entertainment
Mark Wright has won The Apprentice 2014
tvThe Apprentice 2014 final
PROMOTED VIDEO
Life and Style
ebookNow available in paperback
Life and Style
ebooksA superb mix of recipes serving up the freshest of local produce in a delicious range of styles
Latest stories from i100
Have you tried new the Independent Digital Edition apps?

ES Rentals

    Independent Dating
    and  

    By clicking 'Search' you
    are agreeing to our
    Terms of Use.

    iJobs Job Widget
    iJobs General

    Recruitment Genius: Telesales & Customer Service Executives - Outbound & Inbound

    £7 - £9 per hour: Recruitment Genius: Are you outgoing? Do you want to work in...

    Recruitment Genius: National Account Manager / Key Account Sales

    £30000 - £35000 per annum: Recruitment Genius: An opportunity has arisen for a...

    Recruitment Genius: Operations Manager

    £30000 - £35000 per annum: Recruitment Genius: An exciting opportunity to join...

    Recruitment Genius: Recruitment Consultant

    £30000 - £35000 per annum: Recruitment Genius: We have an excellent role for a...

    Day In a Page

    Surrounded by high-rise flats is a little house filled with Lebanon’s history - clocks, rifles, frogmen’s uniforms and colonial helmets

    Clocks, rifles, swords, frogmen’s uniforms

    Surrounded by high-rise flats is a little house filled with Lebanon’s history
    Return to Gaza: Four months on, the wounds left by Israel's bombardment have not yet healed

    Four months after the bombardment, Gaza’s wounds are yet to heal

    Kim Sengupta is reunited with a man whose plight mirrors the suffering of the Palestinian people
    Gastric surgery: Is it really the answer to the UK's obesity epidemic?

    Is gastric surgery really the answer to the UK's obesity epidemic?

    Critics argue that it’s crazy to operate on healthy people just to stop them eating
    Homeless Veterans appeal: Christmas charity auction Part 2 - now LIVE

    Homeless Veterans appeal: Christmas charity auction

    Bid on original art, or trips of a lifetime to Africa or the 'Corrie' set, and help Homeless Veterans
    The week Hollywood got scared and had to grow up a bit

    The week Hollywood got scared and had to grow up a bit

    Sony suffered a chorus of disapproval after it withdrew 'The Interview', but it's not too late for it to take a stand, says Joan Smith
    From Widow Twankey to Mother Goose, how do the men who play panto dames get themselves ready for the performance of a lifetime?

    Panto dames: before and after

    From Widow Twankey to Mother Goose, how do the men who play panto dames get themselves ready for the performance of a lifetime?
    Thirties murder mystery novel is surprise runaway Christmas hit

    Thirties murder mystery novel is surprise runaway Christmas hit

    Booksellers say readers are turning away from dark modern thrillers and back to the golden age of crime writing
    Anne-Marie Huby: 'Charities deserve the best,' says founder of JustGiving

    Anne-Marie Huby: 'Charities deserve the best'

    Ten million of us have used the JustGiving website to donate to good causes. Its co-founder says that being dynamic is as important as being kind
    The botanist who hunts for giant trees at Kew Gardens

    The man who hunts giants

    A Kew Gardens botanist has found 25 new large tree species - and he's sure there are more out there
    The 12 ways of Christmas: Spare a thought for those who will be working to keep others safe during the festive season

    The 12 ways of Christmas

    We speak to a dozen people who will be working to keep others safe, happy and healthy over the holidays
    Birdwatching men have a lot in common with their feathered friends, new study shows

    The male exhibits strange behaviour

    A new study shows that birdwatching men have a lot in common with their feathered friends...
    Diaries of Evelyn Waugh, Virginia Woolf and Noël Coward reveal how they coped with the December blues

    Famous diaries: Christmas week in history

    Noël Coward parties into the night, Alan Clark bemoans the cost of servants, Evelyn Waugh ponders his drinking…
    From noble to narky, the fall of the open letter

    From noble to narky, the fall of the open letter

    The great tradition of St Paul and Zola reached its nadir with a hungry worker's rant to Russell Brand, says DJ Taylor
    A Christmas ghost story by Alison Moore: A prodigal daughter has a breakthrough

    A Christmas ghost story by Alison Moore

    The story was published earlier this month in 'Poor Souls' Light: Seven Curious Tales'