US scientists create mice from two fathers
Sunday 12 December 2010
US scientists have used stem cell technology to create mice from two fathers, an advance that they say could help preserve endangered species and even help same-sex couples have their own genetic children one day.
According to the study published Wednesday in the journal Biology of Reproduction, reproductive scientists in Texas were able to manipulate cells from a male (XY) mouse fetus to produce an induced pluripotent stem (iPS) cell line.
These iPS cells are adult cells that have undergone some genetic reprogramming in order to enter an embryonic stem cell-like state.
Some of the cells that were grown from this new line spontaneously lost their Y chromosome, turning them into XO cells.
Those XO cells were injected into embryos from donor female mice and transplanted into surrogate mouse moms who gave birth to babies with one X chromosome from the original male mouse.
Those babies grew and later mated with normal male mice. Their offspring, both male and female, showed genetic contributions from two fathers.
The study was led by Richard R. Berhringer at the MD Anderson Cancer Center.
Researchers said that with a variation of their technique, "it may also be possible to generate sperm from a female donor and produce viable male and female progeny with two mothers."
However, the study cautioned that the ability to replicate the findings in humans was a long way off.
The "generation of human iPS cells still requires significant refinements prior to their use for therapeutic purposes," the study said.
Previous research has found ways to create mice without any fathers at all, as well as ways to create mice with two mothers.
Life & Style blogs
What is Lyme disease, what are the symptoms and is treatment readily available?
International Kissing Day: Why it feels good
People all over the world are getting semicolon tattoos to draw attention to mental health
The biggest first date turnoff has been revealed
What do the emojis on Snapchat mean?
- 1 Autistic teenager beaten up by bullies makes them watch 20-minute video about autism
- 2 Nick Kyrgios calls former Olympian Dawn Fraser a 'blatant racist' after she tells Wimbledon star to 'go back where their parents came from'
- 3 Chris Moyles reportedly set to make radio comeback with new breakfast show on XFM
- 4 The Greece debt crisis explained in less than 100 words
- 5 Cristiano Ronaldo storms out of interview after being asked about possible sale of Manchester United target Sergio Ramos
£23000 - £27000 per annum: Recruitment Genius: A Business Analyst is required ...
£16000 - £23000 per annum: Recruitment Genius: To succeed, you will need to ha...
£8 per hour: Recruitment Genius: This is an opportunity to join an award winni...
£7 - £9 per hour: Recruitment Genius: Are you outgoing? Do you want to work in...