In fact, our conclusions on page 54 stated that "... [genetic] selection of mutants able to overcome transgene-mediated resistance has not been demonstrated. Although the probability of this hazard cannot be estimated, the appearance of resistance-breaking mutants is unlikely to pose additional harm to untransformed [wild-type] plants when compared to the parental virus."
Moreover, we concluded that the probability of recombination between a virus-derived resistance gene and an infecting RNA virus is much lower than the probability of natural recombination events between two or more viral genomes in multiply-infected plants in the wild. We could go on.
PROF MICHAEL WILSON DR HUGH BARKER
DR TEIFION JONES
DR STUART A MacFARLANE
DR MICHAEL A MAYO DR DAVID J ROBINSON DR SIMON SANTA CRUZ
Scottish Crop Research Institute Dundee