Ford recalled 1.2 million F-150 vehicles on Thursday, after finding a problem with the pick-up truck's airbag system.
Ford said a wiring fault could cause the airbag warning lamp to turn on and the airbag to deploy.
"We urge all of our customers to seek service immediately for an airbag warning lamp that is illuminated."
Ford has marketed the best-selling F-150 as a tough and reliable choice for work and personal use.
The firm said it was not aware of any accidents caused by the fault.
The National Highway Traffic Safety Administration welcomed the move.
"We are pleased that Ford shares our commitment to safety and is taking action to protect consumers," it said in a statement.