Six kilogrammes of crack, worth an estimated pounds 1.2m, were found after the raid in the West End on Friday night.
Andre N'Guessan, 33, of Bryanston Square in the West End, Charles Oppon, 34, of Plummer Road, Streatham and Maxime Keiti, 29, address unknown, will appear at Bow Street magistrates' court today.
Four other people were arrested but were released on police bail until July and August.
Detectives believe they have intercepted a major international manufacturing and distribution network for crack cocaine.
The operation, carried out by the South East Regional Crime Squad, was the culmination of 18 months of work.Reuse content