BRITAIN'S TOP FIVE BIOTECH COMPANIES

Company/development area Market Cap R&D spend 12 months to

at 18 Feb (pounds m) (pounds m)

Shire Pharmaceuticals Group/ 593 27.0 Jun 1998

prescription medicines

Powderject Pharmaceuticals/ 574 7.3 Mar 1998

drug-delivery technology

SkyePharma/ 344 6.1 Dec 1997

prescription pharmaceuticals

Chiroscience Group/ 264 36.4 Feb 1998

pharmaceutical, diagnostic products

Celltech/ 259 21.5 Sep 1998

therapeutic products

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