Capsules make patients grow blood vessels
Wednesday 03 November 1999
The capsules slowly released a growth-promoting substance over a period of several weeks. It improved the flow of blood to the heart and made the patients feel better. Scientists emphasised that the clinical trial involved only 24 patients and further studies on hundreds of volunteers will be needed before the approach could be proved to be an acceptable alternative to coronary bypass surgery.
Instead of grafting arteries or veins from other parts of the body to bypass a clogged heart vessel, the scientists used the slow release of the growth factor to stimulate the regrowth of existing blood vessels.
Michael Simons, associate professor of medicine at Harvard Medical School and a member of the research team, said the technique produced demonstrable improvements. "Patients receiving the highest dose of the growth factor showed an improvement in blood supply and heart function, while the patients receiving the much lower doses of the growth factor or those not receiving the treatment had no increase in blood flow or heart function," Professor Simons said.
Over the past 20 years coronary bypass operations in Britain have increased 20-fold, with about 23,000 operations now being performed each year at a cost of about pounds 4,000 each. Many of the operations are the result of a constriction of the flow of blood to the heart that results in a lack of oxygen and, eventually, to the development of heart disease, which can be lethal. The team of doctors took 24 patients who were unable to have coronary bypass operations for a variety of reasons and who therefore had a portion of their hearts that were inadequately oxygenated.
Eight of the patients had 10 capsules with full-strength growth factor inserted into the fatty deposits next to the inoperable artery, eight received capsules loaded with lower doses and the final eight "controls" received capsules with no growth factor at all. After several weeks, all the patients on the full dose capsules said they had no angina (chest pain associated with badly oxygenated heart muscle), whereas one of the lower dose groups and three of the eight controls complained of chest pains.
Further tests showed that the high-dose capsules had also significantly improved the flow of blood to the heart and substantially reduced the area of heart tissue with inadequate blood flow - from about 19 per cent before the therapy to 9 per cent.
The British Heart Foundation said the concept of using growth factors to repair the heart's arteries was "conceptually exciting" but there was still much work to be done before it could be offered as an alternative to surgery.
- 1 Games of Thrones actor Lena Headey makes emotional promise to her unborn daughter
- 2 Isis burns woman alive for refusing to engage in 'extreme' sex act, UN says
- 4 Female Muay Thai champion hustles coaches to give them a beating
- 5 16-year-old girl beaten and burned alive by lynch mob in Rio Bravo, Guatemala
Isis burns woman alive for refusing to engage in 'extreme' sex act, UN says
Purity balls: Girls in the US making virginity pledges as fathers vow to 'protect purity'
Female Muay Thai champion hustles coaches to give them a beating
Puerto Rico, island of lost dreams: People are leaving the debt-hit territory in droves as near neighbour Cuba's star rises
16-year-old girl beaten and burned alive by lynch mob in Rio Bravo, Guatemala
As a white man, I'm surprised more women aren't tweeting the hashtag #KillAllWhiteMen
Scotland may have to leave the EU even if it votes to stay in, David Cameron confirms
Report finds that Britain's wages are the most unequal in Europe
The day that Britain resigned as a global power
Almost a third of school pupils believe 'Muslims are taking over our country', study claims
SNP fury as HS2 finds 'no business case' for taking fast train service to Scotland
£40-50K: Guru Careers: We are seeking an experienced Software / C# Developer w...
£35 - 40k + Benefits: Guru Careers: We are seeking a Software Developer (JavaS...
£18000 - £23000 per annum + Commission: SThree: As a Trainee Recruitment Consu...