Genes, not greed, make you fat
Thursday 01 December 1994
Scientists at New York's Rockefeller University have made a discovery worth billions of dollars: a gene responsible for obesity in mice and humans. The university has filed for patents to cover the researchers' work, published in today's issue of Nature.
The discovery, by Jeffrey Friedman and five colleagues at the university, will make the diets beloved of magazines and health books redundant. The gene holds the key to the first rationally designed weight-loss pill, one virtually guaranteed to be effective.
Nearly a third of adults in the US are 20 per cent or more overweight. Obesity is a public health problem in all western countries, associated with conditions such as adult-onset diabetes and some cancers.
The gene represents the biochemical ''recipe'' for a hormone secreted by the body's fat cells. This hormone is central to how body weight is regulated: more fatty cells produce more hormone, which cuts appetite or raises energy consumption, thus cutting weight.
By reading the gene sequence, pharmaceutical companies will be able to manufacture the hormone artificially or devise ways of blocking its action. People will be able to alter their natural feedback mechanism and thus control their weight as they like.
Dr Timothy Rink, president of the Californian biotechnology company Amylin Pharmaceuticals, said earlier attempts to control appetite and weight were like ''controlling diabetes before insulin''. The discovery ''translates directly into medical and commercial programmes. A lot of companies that have an interest in metabolism will be very interested.''
Obesity in humans is not dictated by the genes, but by imbalance in the hormonal regulatory system. It is a medical rather than a behavioural problem, says Dr Rink. ''People who are obese - other than food addicts - come to a body weight determined by hormones. Trying to reduce weight by dieting is liable to fail because the basic controlling factor is working against them. Fat people regulate their weight, but at a point they do not feel comfortable with.''
But Dr Rink stressed that although the obesity gene was a key component of weight regulation, it was not the only one. By eating too much sugar ''you can move the balance point''. The gene discovery is not a universal answer, he warned, adding that it would take more than 10 years to produce a rational therapeutic.
- 1 East 17 bandmember Brian Harvey in 'very desperate situation’
- 2 Is this bridge haunted by the ghost of nu rave?
- 3 Woman filmed launching racist tirade against men on the Tube for speaking in 'own lingo'
- 4 The West has it totally wrong on Lee Kuan Yew
- 5 Scientists have discovered a simple way to cook rice that dramatically cuts the calories
East 17 bandmember Brian Harvey in 'very desperate situation’
Is this bridge haunted by the ghost of nu rave?
Woman filmed launching racist tirade against men on the Tube for speaking in 'own lingo'
Saudi Arabia says it won't rule out building nuclear weapons
Germanwings plane crash: Andreas Lubitz 'had eyesight problems' and woke from nightmares 'screaming we’re going down'
Ukip supporters are 55 or older, white and socially conservative, finds British Social Attitudes Report
JK Rowling responds to fan tweeting she 'can't see' Dumbledore being gay
Jeremy Clarkson sacked live: Alan Yentob 'wouldn't rule out' ex Top Gear host's BBC return
David Cameron calls Labour 'hopeless, sneering socialists' while announcing 7-day NHS plans
Revealed: Putin's army of pro-Kremlin bloggers
The West has it totally wrong on Lee Kuan Yew
£6 per hour: Recruitment Genius: This is an exciting opportunity to join a gro...
Negotiable: Recruitment Genius: A Service Delivery Manager is required to join...
£12000 - £24000 per annum: Recruitment Genius: A opportunity has arisen for a ...
£32000 - £38000 per annum: Ashdown Group: A successful accountancy practice in...