BBC 5Live's radio presenter Shelagh Fogarty was left cowering on her chair after a mouse was seen scurrying across the studio.
Fogarty was live on the air and mid-way through a serious discussion when her interviewee saw the rodent running across the floor.
The presenter started squealing before kneeling on her chair much to the amusement of her interviewee and colleagues in the room.
The mouse running across the floor caused a panicked Fogarty to leap out of her chair saying: "Oh my God, how horrible. Oh gosh, I'm sorry, I'm live on the radio squealing and saying how horrible and kneeling on my chair because there is a mouse in the room."
Fogarty quickly brought the interview to an end, telling listeners: "I'm going to leave it there because I'm not sure I can continue interviewing in a serious manner when I know there's a mouse scurrying around my feet."
She sat up on her chair and told the audience she was "just about OK", adding: "But these feet aren't touching the ground, I've got big boots on as well. There's no way this mouse could do me harm, it's quite ridiculous.
"Please somebody get rid of the mouse. If it walks on my hand, I'm resigning. It's on the bloody table!"
The journalist, who joined the station in 1999 and has worked on its drivetime and breakfast shows, later tweeted: "I've covered tsunamis, terrorist attacks, riots, gun culture - and a mouse tips me over the edge. La Condition Humaine."