"I don't think I want my career to go on and on," she said. "I want to retire quite soon. I want to live in the English countryside and paint bad pictures of horrible little landscapes." She added: "I feel this unbelievable depression when I open the pages of the Sunday papers - everyone looks so glamorous."
The confession, which emerged shortly before Mirren was due to attend the premiere of Some Mother's Son in which she has a has starring role, will be a blow for those who have avidly followed her progress through the five Prime Suspect series as Chief Inspector Jane Tennison, a role which catapulted her into the nation's hearts. As the chain-smoking detective she conquered police sexism and prejudice to solve numerous fictional murders.
Despite her popularity, however, the actress, who was 50 last year, will reveal to Wax in a BBC series beginning on 20 January that she is deeply insecure about her abilities and looks.
"I'm sick of the ambition, I'm so sick of this continual feeling of frustration - thinking am I doing it right? I'm not doing it right, I'm doing it terribly," she said. She also told Wax : "I'm really quite happy not to work."
Ms Mirren was allegedly asked to make a guest appearance on Saturday night's National Lottery show. But BBC chiefs reportedly shelved the idea because of the sensitivity surrounding the film and the Irish peace process.
It is a charge the BBC strenuously denies, saying Ms Mirren is one of several possible future National Lottery guests.
Asked about the lottery show, she said: "I was a little bit upset. I wasn't angry but I was looking forward to it. But I'm sure they'll ask me back again."
Wax also interviews Pamela Anderson, who reveals her favourite sexual position.