Nobel prize for work that led to Viagra discovery

THE DISCOVERY that a simple gas - a pollutant in car exhausts - acts as a key chemical messenger in the body has won this year's Nobel prize for medicine.

Three American scientists share the prize for their independent lines of research which led to the finding that nitric oxide can stimulate blood vessels to dilate around the heart and other vital organs when released inside the body.

The work also led to groundbreaking investigations of cardiovascular disease, cancer and the complex chemistry of the male erection, which led to the discovery of the anti-impotence effects of Viagra.

Three pharmacologists, Robert Furchgott, at the State University of New York, Ferid Murad, at the University of Texas Medical School in Houston, and Louis Ignarro, at the University of California, Los Angeles, share the prize of 7.6 million Swedish crowns (pounds 570,000).

Dr Furchgott, now 82, found that some drugs sometimes dilated blood vessels and on other occasions caused them to contract. In 1980 he proposed an unknown "relaxing factor" that could be responsible.

"I'm surprised, although I knew that my name was among those that were up for the prize this year and I guess I had some good friends voting," Dr Furchgott said yesterday.

Dr Murad, 62, discovered in 1977 that some muscle cells release nitric oxide when they relax and speculated that hormones could act on the gas. But it was Dr Ignarro, 57, who performed what the Nobel prize committee called a "brilliant series of analyses" to conclude that nitric oxide was Dr Furchgott's and Dr Murad's mysterious signalling factor.

Since then, nitric oxide has been shown to play a crucial role in the treatment of disorders due to heart problems, shock, lung disease, cancer and impotence.

It is now known that nitroglycerine, a common treatment for cardiovascular disease, works by releasing nitric oxide which increases blood flow to the heart. The Karolinska Institute in Stockholm, which runs the Nobel prize for medicine, said that Alfred Nobel, who set up the prize after inventing dynamite, was advised by doctors a century ago to take nitroglycerine for his chest pains.

"It has been known since the last century that the explosive nitroglycerine has beneficial effects against chest pain. However, it would take 100 years until it was clarified that nitroglycerin acts by releasing the gas," the Karolinska Institute said.

Life and Style
A teenager boy wakes up.
life
Life and Style
Researchers have said it could take only two questions to identify a problem with alcohol
food + drink
Arts and Entertainment
Critics say Kipling showed loathing for India's primitive villagers in The Jungle Book
filmChristopher Walken, Bill Murray, Scarlett Johanssen Idris Elba, Andy Serkis, Benedict Cumberbatch, Cate Blanchett and Christian Bale
Life and Style
Playing to win: for Tanith Carey, pictured with Lily, right, and Clio, even simple games had to have an educational purpose
lifeTanith Carey explains what made her take her foot off the gas
PROMOTED VIDEO
Have you tried new the Independent Digital Edition apps?
News
ebooksAn unforgettable anthology of contemporary reportage
Life and Style
tech
Arts and Entertainment
A still from Duncan Campbell's hour-long film 'It for Others'
Turner Prize 2014
Life and Style
food + drink
News
i100
Arts and Entertainment
Tony Hadley in a scene from ‘Soul Boys Of The Western World’
musicSpandau Ballet are back together - on stage and screen
Arts and Entertainment
From left to right: Ed Stoppard as Brian Epstein, Sheridan Smith as Cilla Black and Elliott Cowan as George Martin in 'Cilla'
tvCilla review: A poignant ending to mini-series
News
i100
Life and Style
Bearing up: Sebastian Flyte with his teddy Aloysius in Brideshead Revisited
lifePhilippa Perry explains why a third of students take a bear to uni
Arts and Entertainment
Sir Alan Sugar appearing in a shot from Apprentice which was used in a Cassette Boy mashup
artsA judge will rule if pieces are funny enough to be classed as parodies
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

LSA (afterschool club) vacancy in Newport

£40 per day + Travel Scheme : Randstad Education Cardiff: The Job: Our client ...

Trust Accountant - Kent

NEGOTIABLE: Austen Lloyd: TRUST ACCOUNTANT - KENTIf you are a Chartered Accou...

Geography Teacher

£85 - £120 per day: Randstad Education Cheshire: randstad education are curre...

Teaching Assistant

Negotiable: Randstad Education Group: You must:- Speak English as a first lang...

Day In a Page

Isis is an hour from Baghdad, the Iraq army has little chance against it, and air strikes won't help

Isis an hour away from Baghdad -

and with no sign of Iraq army being able to make a successful counter-attack
Turner Prize 2014 is frustratingly timid

Turner Prize 2014 is frustratingly timid

The exhibition nods to rich and potentially brilliant ideas, but steps back
Last chance to see: Half the world’s animals have disappeared over the last 40 years

Last chance to see...

The Earth’s animal wildlife population has halved in 40 years
So here's why teenagers are always grumpy - and it's not what you think

Truth behind teens' grumpiness

Early school hours mess with their biological clocks
Why can no one stop hackers putting celebrities' private photos online?

Hacked photos: the third wave

Why can no one stop hackers putting celebrities' private photos online?
Royal Ballet star dubbed 'Charlize Theron in pointe shoes' takes on Manon

Homegrown ballerina is on the rise

Royal Ballet star Melissa Hamilton is about to tackle the role of Manon
Education, eduction, education? Our growing fascination with what really goes on in school

Education, education, education

TV documentaries filmed in classrooms are now a genre in their own right
It’s reasonable to negotiate with the likes of Isis, so why don’t we do it and save lives?

It’s perfectly reasonable to negotiate with villains like Isis

So why don’t we do it and save some lives?
This man just ran a marathon in under 2 hours 3 minutes. Is a 2-hour race in sight?

Is a sub-2-hour race now within sight?

Dennis Kimetto breaks marathon record
We shall not be moved, say Stratford's single parents fighting eviction

Inside the E15 'occupation'

We shall not be moved, say Stratford single parents
Air strikes alone will fail to stop Isis

Air strikes alone will fail to stop Isis

Talks between all touched by the crisis in Syria and Iraq can achieve as much as the Tornadoes, says Patrick Cockburn
Nadhim Zahawi: From a refugee on welfare to the heart of No 10

Nadhim Zahawi: From a refugee on welfare to the heart of No 10

The Tory MP speaks for the first time about the devastating effect of his father's bankruptcy
Witches: A history of misogyny

Witches: A history of misogyny

The sexist abuse that haunts modern life is nothing new: women have been 'trolled' in art for 500 years
Shona Rhimes interview: Meet the most powerful woman in US television

Meet the most powerful woman in US television

Writer and producer of shows like Grey's Anatomy, Shonda Rhimes now has her own evening of primetime TV – but she’s taking it in her stride
'Before They Pass Away': Endangered communities photographed 'like Kate Moss'

Endangered communities photographed 'like Kate Moss'

Jimmy Nelson travelled the world to photograph 35 threatened tribes in an unashamedly glamorous style