Chelsea Clinton, the daughter of former US President Bill Clinton and ex-Secretary of State Hilary Clinton, is expecting her first child this autumn.
The 34-year-old, who is married to investment banker Marc Mevinsky, made the announcement Thursday at the end of a Clinton Foundation event in New York on empowering girls.
Standing on stage alongside her mother, Chelsea Clinton told the group of female students that she feels "all the better whether it's a girl or a boy that she or he will grow up in a world with so many strong female leaders".
"I just hope I will be as good a mum to my child and hopefully children as my mum was to me," she said.
The former first lady, who is said to be eyeing up the presidency in 2016, said she was "really excited" about becoming a grandmother.
"It makes this work even more important because we've made a lot of progress," Ms Clinton said.
"I want to see us keep moving and certainly for future generations as well so that maybe our grandchild will not have to be worried about some of the things that young women and young men are worried about today."
On Twitter she wrote:
My most exciting title yet: Grandmother-To-Be! @billclinton and I are thrilled that Chelsea and Marc are expecting their first child!- Hillary Clinton (@HillaryClinton) April 17, 2014
The former President also tweeted his excitement about the news:
Excited to add a new line to my Twitter bio...grandfather-to-be! @hillaryclinton and I are so happy for Chelsea and Marc!- Bill Clinton (@billclinton) April 17, 2014
The announcement comes amid speculation about a new addition to the Clinton family. In an interview with Glamour magazine last year Chelsea Clinton revealed that she and her husband were hoping to start a family soon and dubbed 2014 "the year of the baby".
Preparations for the newborn will run parallel with Hilary Clinton's consideration over whether to launch another campaign for the White House. The former secretary of state is expected to announce her decision later this year. A potential presidential campaign would coincide with her future grandchild's formative years.
Chelsea Clinton grew up under the pubic gaze in the White House before graduating from Stanford University and Columbia University's Mailman School of Public Health. She worked in New York for a hedge fund and a management consulting firm.
She and Marc Mezvinsky, the son of two former members of Congress, were married in Rhinebeck, New York, in July 2010. The former first daughter has since pursued a number of ventures, including studying for a doctorate from Oxford University, where her father was a Rhodes Scholar, while taking a leading role in her family's foundation.
Chelsea Clinton is the vice chair of the family foundation, which was renamed the Bill, Hillary and Chelsea Clinton Foundation. She helps to direct the organisation's humanitarian and philanthropic efforts around the globe. She also serves as a special correspondent for NBC News.
She has evaded voicing her views regarding her mother's potential bid for the White House but has said she will support her in whatever decision she makes. However, her influence would likely attract younger voters if the former secretary of state decides to seek the presidency.
Additional reporting by Associated Press