Queen guitarist Brian May features on Lady Gaga's 'Born This Way' album.
The legendary rocker plays on a track called 'You & I' in a collaboration which is a dream come true for the 25-year-old singer.
A source close to the star told the Daily Mirror newspaper: "It's always been Gaga's dream to perform as Queen. If it wasn't for Queen, there would be no Gaga.
"This collaboration with Brian May means the world to her."
Gaga - real name Stefani Germanotta - even took her name from a Queen song, inspired by her ex-boyfriend and former producer Rob Fusari, who would sing the band's track 'Radio Gaga' to her in the studio before she became famous.
The 'Judas' hitmaker has also spoken of her admiration for the band's frontman Freddie Mercury - who died in 1991 -saying she looks to him for inspiration because he had his own unique on stage personality.
She said: "Freddie was unique - one of the biggest personalities in the whole of pop music. He was not only a singer but a fantastic performer, a man of the theatre, who constantly transformed himself. In short: a genius."