Oscar-winning actor Philip Seymour Hoffman died accidentally after taking a toxic mix of drugs, New York City officials announced on Friday.
Hoffman died from a mix of heroin, cocaine, amphetamines and benzodiazepines, said a spokeswoman for the New York City medical examiner.
Law enforcement officials have confirmed that Hoffman was found on 2 Feb with a needle in his arm, and tests found heroin in samples from at least 50 packets in his Manhattan apartment.
Police had been investigating his death as a suspected drug overdose, but an autopsy in February was inconclusive and medical examiners said more tests were needed.
Authorities also found unused syringes, a charred spoon and various prescription medications, including a drug used to treat heroin addiction, a blood-pressure medication and a muscle relaxant in his apartment.
Philip Seymour Hoffman 1967 - 2014
Philip Seymour Hoffman 1967 - 2014
A classic shot of Philip Seymour Hoffman as Capote, the role which earned him a Best Actor Academy Award in 2006
2/25 Scent Of A Woman
Hoffman played an affable school boy in 1992 film Scent Of A Woman
3/25 Boogie Nights
Philip Seymour Hoffman, Mark Wahlbergand JohnC Reilly in 'Boogie Nights', 1997
Philip Seymour Hoffman and Lara Flynn Boyle in 'Happiness', 1998
5/25 The Big Lebowski
Philip Seymour Hoffman and Jeff Bridges in 'The Big Lebowski', 1998
Dressed up to the nines in Flawless, 1999
7/25 The Talented Mr Ripley
Another career highlight for Hoffman, in 1999
Philip Seymour Hoffman stars as Phil Parma in 'Magnolia'. This was Paul Thomas Anderson's second film, 1999
9/25 Almost Famous
Philip Seymour Hoffman as Lester Bangs and Patrick Fugit as William Miller in 'Almost Famous', 2000
10/25 Punch Drunk
Hoffman poses in Punch Drunk Love, 2002
11/25 Owning Mahowny
Philip Seymour Hoffman in 'Owning Mahowny', 2003
Philip Seymour Hoffman portrays writer Truman Capote in a scene from the film, 'Capote'. The film looks at the author's journey into writing 'In Cold Blood', 2006
13/25 Mission Impossible III
Philip Seymour Hoffman stars in 'Mission Impossible III', 2006
14/25 Charlie Wilson's War
A scene from 'Charlie Wilson's War' with Tom Hanks as Charlie Wilson, left, and Philip Seymour Hoffman as Gust Avrakotos, right. The film follows Charlie Wilson, a congressman from Texas, who takes an interest in the situation in Afghanistan, 2007
15/25 The Savages
Philip Seymour Hoffman, left, and Laura Linney, right, are shown in this scene from the film 'The Savages'. The film centers on Jon and Wendy Savage and their broken relationship with their father, 2007
Philip Seymour Hoffman portrays Father Flynn, right, and Meryl Streep portrays Sister Aloysius in a scene from 'Doubt'. Streep plays Sister Aloysius who sets off on a personal mission to find out the truth about Father Flynn, 2008
As a man of the cloth, starring opposite Meryl Streep in Doubt, 2008
18/25 Synecdoche, New York
Philip Seymour Hoffman and Hope Davis in Charlie Kaufman's ambitious directorial debut 'Synecdoche, New York', 2008
19/25 'Jack Goes Boating'
Philip Seymour Hoffman makes his directorial debut as he stars alongside Amy Ryan in 'Jack Goes Boating', 2010
20/25 The Ides of March
Philip Seymour Hoffman, left, and Ryan Gosling are shown in a scene from 'The Ides of March', 2011
A truly versatile actor, Hoffman played a baseball coach opposite Brad Pitt in the Oscar-nominated Moneyball, 2011
22/25 The Master
Joaquin Phoenix, left, and Philip Seymour Hoffman in a scene from 'The Master'. The director, Paul Thomas Anderson, acknowledged that Hoffman's character was partially based on Church of Scientology founder L. Ron Hubbard, 2012
23/25 A Late Quartet
Philip Seymour Hoffman in the pleasing 'A Late Quartet', 2012
24/25 Death Of A Salesman
Philip Seymour Hoffman, left, and Andrew Garfield, right, take a curtain call at the Broadway opening night of 'Death Of A Salesman' at the Barrymore Theatre, 2012
25/25 The Hunger Games: Catching Fire
Philip Seymour Hoffman starring alongside Woody Harrelson in 'The Hunger Games: Catching Fire', 2013
46-year-old Hoffman had been frank about his struggle with substance abuse.
He said on US TV in 2006 that had he used “anything I could get my hands on” before getting clean at age 22.
But he admitted last year that he had relapsed and had developed a heroin problem for which he had gone to rehab.
Police have been investigating how Hoffman obtained the heroin.
Tests on the drug found in his apartment showed that it was not cut with the dangerous additive fentanyl, a synthetic form of morphine used to intensify the high that has been linked to deaths in other states.
Additional reporting by AP