A family affair: How genetic mixing has affected us all

From Mogul warriors to European traders on the Silk Road, a new map shows history’s great migrations have left a genetic mark on peoples across the world

Genghis Khan may have been the most famous ruler of what would become the largest empire the world has ever seen, but despite the Mongol realm collapsing long after his death scientists have now revealed the 13th-century warrior’s genetic legacy continues to this day.

The genetic histories of 95 different populations across the world – showing the likely impact of Khan’s transcontinental empire as well as European colonialism, the Arab slave trade and European traders on the Silk Road mixing with people in China – have been revealed for the first time. Displayed in an interactive map, the work identifies, dates and characterises genetic mixing between populations.

Research has already shown the Hazara people of Pakistan are partially descended from Mongol warriors, based on historical, linguistic and oral tradition. But a team from Oxford University and University College London has revealed clear evidence of Mongol DNA entering the population during 1306 – exactly 100 years after Genghis Khan was pronounced ruler of all Mongols.

Six other populations, from as far west as Turkey, showed similar evidence of genetic mixing with Mongols around the same time as soldiers had children with women from areas they conquered. The Uyghur people in China are estimated to have a 50 per cent proportion of ‘Mongol-like’ genetic mixture, Uzbheks a 39 per cent proportion. and Turkish eight per cent – showing a progressive west-ward decrease in Mongol ancestry.

Using what the authors have christened their “Globetrotter” technique, the map allows people to select a population revealing “past admixture events”. This reveals the histories of the genetic mixing that created them, between populations across Europe, Africa, Asia and South America spanning the past four millennia.

Dr Garrett Hellenthal, of the UCL Genetics Institute the study’s lead author, said the team was able to pinpoint the year or time frame when genetic mixing took place using genetic recombination – the biological process in which two DNA molecules exchange genetic information.

“Although individual mutations carry only weak signals about where a person is from, by adding information across the whole genome we can reconstruct these mixing events. Sometimes individuals sampled from nearby regions can have surprisingly different sources of mixing,” he said.

“For example, we identify distinct events happening at different times among groups sampled within Pakistan, with some inheriting DNA from sub-Saharan Africa, perhaps related to the Arab Slave Trade, others from East Asia, and yet another from ancient Europe. Nearly all our populations show mixing events, so they are very common throughout recent history and often involve people migrating over large distances.”

Sophisticated statistical analysis using genome data from 1,490 individuals across the 95 areas was used to identify “chunks” of DNA shared between individuals from different groups.

Co-author Dr Daniel Falush, from the Max Planck Institute for Evolutionary Anthropology in Leipzig, said: “Each population has a particular genetic ‘palette’. If you were to paint the genomes of people in modern-day Maya, for example, you would use a mixed palette with colours from Spanish-like, West African and Native American DNA. This mix dates back to around 1670CE, consistent with historical accounts describing Spanish and West African people entering the Americas around that time.

“Though we can’t directly sample DNA from the groups that mixed in the past, we can capture much of the DNA of these original groups as persisting, within a mixed palette of modern-day groups.”

The UK showed no strong evidence of admixture, however. “This doesn’t mean something didn’t happen but British genetic mixture is generally made up from people of the same part of the world rather than from different genetic groups like we see elsewhere,” said Dr Hellenthal.

Dr Simon Myers, of Oxford University’s Department of Statistics and Wellcome Trust Centre for Human Genetics who co-authored the study, said: “DNA really has the power to tell stories and uncover details of humanity’s past.

“For example, the DNA of the Tu people in modern China suggests that in around 1200, Europeans similar to modern Greeks mixed with an otherwise Chinese-like population. Plausibly, the source of this European-like DNA might be merchants travelling the nearby Silk Road.”

The team’s research, published in Science this week, could have implications for how DNA impacts health and disease in different groups.

“Some populations are more at risk of certain diseases than others, and drug efficacy is also known to vary significantly. Rare genetic mutations are particularly likely to show strong differences between populations, and understanding their role in our health is an area of intense current research efforts,” Dr Myers said.

“We hope in future to include even more detailed sequencing o spot these rare mutations and better understand their global spread. ”

Dr Hellenthal told The Independent future research would include a more detailed study of the UK’s genetic mixture. He said: “We’re looking at a more targeted approach in areas such as Ethiopia and a substantial number of groups in America. We’re also going to be studying the United Kingdom to get a better genetic picture of local regions.”

View the map at http://admixturemap.paintmychromosomes.com

Start your day with The Independent, sign up for daily news emails
Life and Style
A monstrous idea? Body transplants might no longer be science fiction
Science An Italian neurosurgeon believes so - and it's not quite as implausible as it sounds, says Steve Connor
Sport
Demba Ba (right) celebrates after Besiktas win on penalties
footballThere was no happy return to the Ataturk Stadium, where the Reds famously won Champions League
Arts and Entertainment
Natural beauty: Aidan Turner stars in the new series of Poldark
arts + ents
News
Mia Freedman, editorial director of the Mamamia website, reads out a tweet she was sent.
arts + ents
ebooks
ebooksA special investigation by Andy McSmith
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Recruitment Genius: Bookkeeper

£23000 - £26000 per annum: Recruitment Genius: This small, friendly, proactive...

Recruitment Genius: Photographic Event Crew

£14500 - £22800 per annum: Recruitment Genius: This is a fantastic opportunity...

Recruitment Genius: Software Developers - .NET / ASP.NET / WebAPI / JavaScript

Negotiable: Recruitment Genius: A Software Developer is required to join a lea...

Austen Lloyd: Corporate Tax Solicitor - City

Excellent Salary: Austen Lloyd: A first rate opportunity to join a top ranking...

Day In a Page

HIV pill: Scientists hail discovery of 'game-changer' that cuts the risk of infection among gay men by 86%

Scientists hail daily pill that protects against HIV infection

Breakthrough in battle against global scourge – but will the NHS pay for it?
How we must adjust our lifestyles to nature: Welcome to the 'Anthropocene', the human epoch

Time to play God

Welcome to the 'Anthropocene', the human epoch where we may need to redefine nature itself
MacGyver returns, but with a difference: Handyman hero of classic 1980s TV series to be recast as a woman

MacGyver returns, but with a difference

Handyman hero of classic 1980s TV series to be recast as a woman
Tunnel renaissance: Why cities are hiding roads down in the ground

Tunnel renaissance

Why cities are hiding roads underground
'Backstreet Boys - Show 'Em What You're Made Of': An affectionate look at five middle-aged men

Boys to men

The Backstreet Boys might be middle-aged, married and have dodgy knees, but a heartfelt documentary reveals they’re not going gently into pop’s good night
Crufts 2015: Should foreign dogs be allowed to compete?

Crufts 2015

Should foreign dogs be allowed to compete?
10 best projectors

How to make your home cinema more cinematic: 10 best projectors

Want to recreate the big-screen experience in your sitting room? IndyBest sizes up gadgets to form your film-watching
Manchester City 1 Barcelona 2 player ratings: Luis Suarez? Lionel Messi? Joe Hart? Who was the star man?

Manchester City vs Barcelona player ratings

Luis Suarez? Lionel Messi? Joe Hart? Who was the star man at the Etihad?
Arsenal vs Monaco: Monaco - the making of Gunners' manager Arsene Wenger

Monaco: the making of Wenger

Jack Pitt-Brooke speaks to former players and learns the Frenchman’s man-management has always been one of his best skills
Cricket World Cup 2015: Chris Gayle - the West Indies' enigma lives up to his reputation

Chris Gayle: The West Indies' enigma

Some said the game's eternal rebel was washed up. As ever, he proved he writes the scripts by producing a blistering World Cup innings
In Ukraine a dark world of hybrid warfare and murky loyalties prevails

In Ukraine a dark world of hybrid warfare

This war in the shadows has been going on since the fall of Mr Yanukovych
'Birdman' and 'Bullets Over Broadway': Homage or plagiarism?

Homage or plagiarism?

'Birdman' shares much DNA with Woody Allen's 'Bullets Over Broadway'
Broadchurch ends as damp squib not even David Tennant can revive

A damp squib not even David Tennant can revive

Broadchurch, Series 2 finale, review
A Koi carp breeding pond, wall-mounted iPads and a bathroom with a 'wellness' shower: inside the mansion of Germany's 'Bishop of Bling'

Inside the mansion of Germany's 'Bishop of Bling'

A Koi carp breeding pond, wall-mounted iPads and a bathroom with a 'wellness' shower