Faulty gene may cause Alzheimer's in women
Monday 12 January 2009
Medicine A faulty gene on the female X chromosome may contribute to the development of Alzheimer's disease in women, scientists said yesterday.
The discovery is the first evidence of a sex-specific risk factor for the disease. Scientists identified a variant in the gene PCDH11X that significantly correlated with susceptibility to late-onset Alzheimer's disease (Load).
When the data was analysed to account for sex, the association was found to be almost entirely confined to women. PCDH11X lies on the female X chromosome, one of the "packages" of DNA inside the cell nucleus.
It provides the coded building instructions for a protein called protocadherin.
There is evidence that protocadherins may be affected by an enzyme linked to early-onset forms of Alzheimer's. Dr Steven Younkin of the Mayo Clinic College of Medicine in Jacksonville, Florida, led the research, reported in the Nature Genetics. The researchers wrote: "Further study should open new therapeutic possibilities for this devastating disease."
- 1 Florida man sentenced to two-and-a-half years for having sex on the beach in front of a child
- 2 Autistic teenager beaten up by bullies makes them watch 20-minute video about autism
- 4 World learns of app that shows you who unfriended you on Facebook, app promptly crashes
- 5 Chris Moyles reportedly set to make radio comeback with new breakfast show on XFM
More Britons believe that multiculturalism makes the country worse - not better, says poll
Osborne to cap family benefits at £23,000 – announced ahead of his post-election Budget
Nathan Collier: Montana man inspired by same-sex marriage ruling requests right to wed two wives
Sickness and disability benefits could be reduced by £30 a week as part of £12bn welfare cuts
Greece debt crisis: Angela Merkel and Francois Hollande issue Athens with 24-hour ultimatum to avoid crashing out of the euro
Greece crisis: Referendum exposes a gaping hole at the heart of the European Union – its lack of genuine legitimacy
£23000 - £27000 per annum: Recruitment Genius: A Business Analyst is required ...
£16000 - £23000 per annum: Recruitment Genius: To succeed, you will need to ha...
£8 per hour: Recruitment Genius: This is an opportunity to join an award winni...
£7 - £9 per hour: Recruitment Genius: Are you outgoing? Do you want to work in...