Scientists link autism with higher testosterone levels
Powerful evidence has emerged that may soon lead scientists to discover the causes of autism which, in one form or another, now affects about one in every 100 children in Britain.
Scientists have found that raised levels of the sex hormone testosterone in the womb of pregnant women is a significant risk factor in whether a child develops autistic characteristics.
The researchers emphasised yesterday that although they cannot prove testosterone exposure in the womb causes autism, they strongly believe it may be the smoking gun that eventually leads to the source of the brain disorder. Professor Simon Baron Cohen of Cambridge University said 235 healthy children whose mothers had amniocentesis – a womb test during pregnancy – were closely monitored for eight years and tested for autistic-like behaviour at regular intervals during their development.
The scientists found that high levels of testosterone in the amniotic fluid of the womb were significantly correlated with autistic-like behaviour, such as whether the child tends to be more unsociable or less empathetic than normal.
"It's a significant correlation and it's a correlation that remains significant after you have controlled for a whole set of other factors," Professor Baron Cohen told the British Association's Science Festival at York University.
Previous work on animals has suggested that testosterone in the womb may affect the early development of the brain, which in humans might lead to the sort of extreme behaviour typical of autistic spectrum disorder, including Asperger's syndrome.
"What we knew before this study was that foetal testosterone was showing a correlation with social development at earlier points in childhood," the scientist went on. "But we hadn't been able to look at so-called autistic traits before, so in that respect this is something new.
"The idea that foetal testosterone actually plays a causal role in autism is just a hypothesis. So there is no evidence from any lab in the world that this is actually a causal factor, but this research is certainly consistent with that hypothesis."
Professor Baron Cohen has pioneered the "extreme male brain" theory to explain that autism and its related disorders may be a manifestation of being at the end of a wide spectrum of behaviours seen typically in little boys rather than little girls.
Autistic characteristics for instance includes a fascination with numbers and systems – such as collecting cards – rather than conversational play with other children, which typifies the sort of behaviour seen more commonly in small girls.
"Children with autism seemed to have an exaggeration of the typical male profile because they have a very strong interest in systems, like numbers, but have difficulties with empathy," Professor Baron Cohen added.
Cases of autism – or more accurately autistic spectrum disorder – have increased dramatically over the past 30 years. But this is almost certainly due to better diagnosis and a broadening of the definition to cover other conditions, rather than a real increase.
The ethical dilemma
Professor Simon Baron Cohen is a leading proponent of the theory that autistic spectrum disorder represents the extreme end of the range of behaviours commonly seen in little boys rather than little girls: like many autistic children, boys tend to "systemise" rather than "empathise". The professor calls it the "extreme male brain hypothesis", and the latest study on testosterone levels in the womb is consistent with the idea that when brain development becomes "too male" under the influence of the sex hormone, it results in autistic-like behaviour seen in little boys. If testosterone levels are shown to cause – or partly cause – autism it will raise the ethical issue of what should be done medically. To lower testosterone levels in the womb deliberately may decrease risk of autism, but it would almost certainly interfere with normal foetal development.
- 1 Planes go hybrid-electric in important step to greener flight
- 4 Hip hop is both racial and political, and for Iggy Azalea to suggest otherwise is insulting
- 5 Man hospitalised with pneumonia after downing eggnog at office Christmas party
Antonio Martin shooting: Black teenager may have tried to ambush patrolman, says police officer's lawyer
Orphan kangaroos spend Christmas without their parents
Northern Lights above Britain: Stunning Aurora Borealis illuminates Northumberland sky on Christmas Eve
New route to Mars could make manned mission much cheaper and easier
Isis 'did not shoot down Jordan war plane' before capturing pilot, says US
British actor Idris Elba cannot star as James Bond because he is black, says shock jock Rush Limbaugh
Rozanne Duncan: Ukip expels councillor for 'jaw-dropping' comments made in BBC TV interview
Germany anti-Islam protests: 17,000 march on Dresden against 'Islamification of the West'
Ukip member gets into Christmas spirit with Union Flag plea to Santa 'for our country back'
BBC director Danny Cohen: Rising UK antisemitism makes me feel more uncomfortable than ever
Alex Salmond has 'broken his word to the Scottish people' says Scottish Lib Dem leader
£20000 - £35000 per annum: Recruitment Genius: This full service social media ...
£24000 - £35000 per annum: Recruitment Genius: We are 'Changemakers in retail'...
Very Competitive: Austen Lloyd: Senior Conveyancer - South West We are see...
Excellent Salary: Austen Lloyd: DORSET MARKET TOWN - SENIOR PROPERTY SOLICITOR...