Technique to convert blood types could end shortages
Monday 02 April 2007
Scientists have developed a simple method of converting blood from one group to another.
The breakthrough could potentially mean the end of blood shortages by boosting much-needed supplies of group O negative blood. That blood type is known as "universal" because it can be given to anyone. Giving patients the wrong blood type can result in death.
Writing in the journal Nature Biotechnology, an international team of researchers described how they converted blood from group A, B or AB to group O. The process uses bacterial enzymes as biological "scissors" to cut sugar molecules from the surface of red blood cells.
People in groups A and B have blood containing one of two different sugar molecules which can trigger an immune response. Those in group O have neither of these "antigens", while those in group AB have both.
The scientists, led by Professor Henrik Clausen, from the University of Copenhagen in Denmark, started by screening 2,500 types of fungi and bacteria looking for useful proteins.
Two bacteriums, Elizabethkingia meningosepticum, and Bacteroides fragilis, yielded enzymes capable of removing both A and B antigens from red blood cells.
That was verified by standard laboratory tests. After an hour's exposure to the appropriate enzyme, the antigens vanished from 200 millilitre samples of A, B and AB blood.
The researchers wrote: "Clinical translation of this approach may allow improvement of the blood supply and enhancement of patient safety in transfusion medicine."
Patient trials will have to take place before group O blood produced by the conversion method can be used in hospitals.
- 1 Michael Brown shooting: Police shoot and kill second young black man near Ferguson
- 2 James Foley 'beheaded': Isis video shows militant with British accent 'execute US journalist' – and warns Obama of more to come
- 3 ALS ice bucket challenge co-founder Corey Griffin drowns aged 27
- 4 Cilla Black defends Cliff Richard: 'I am positive that the allegations are without foundation'
- 5 James Foley 'beheading': Met police warn public watching murder video could be criminal offence
James Foley 'beheaded': PM cuts holiday short for emergency meeting on British response to latest Isis atrocity
Michael Brown shooting: Police shoot and kill second young black man near Ferguson
ALS ice bucket challenge co-founder Corey Griffin drowns aged 27
James Foley 'beheaded': Isis video shows militant with British accent 'execute US journalist' – and warns Obama of more to come
Iraq crisis: Islamic State's message to America - 'We will drown you all in blood'
Scottish independence: English people overwhelmingly want Scotland to stay in the UK
Isis threat: Cameron wants an alliance with Iran
Crisis? What crisis? A visiting US doctor gives the NHS a rave review
Ukip MEP calls for reintroduction of death penalty on fiftieth anniversary of last deaths
Russell Brand calls for Israel boycott: Comedian urges big businesses that 'facilitate the oppression of people in Gaza' to pull funding
Michael Brown shooting: Chaos erupts on the streets of Ferguson after autopsy shows teenager was shot six times – twice in the head
Negotiable: Harrington Starr: C# .NET Software Developer (Client-Side, SQL, VB...
£40000 - £60000 per annum + Benefits + Bonus: Harrington Starr: C# Developer (...
£55000 - £65000 per annum + Benefits + Bonus: Harrington Starr: C# Full Stack ...
£450 - £600 per day: Harrington Starr: AIFMD Business Analyst / Consultant - I...