Tibetans inherited 'super gene' from extinct humans to survive life on the Roof of the World
Study suggests EPAS1 was passed from the recently-discovered Denisovans to Tibetans so that their bodies acclimatised better to high altitudes
As the highest region on the planet, the Tibetan Plateau is often referred to as 'the Roof of the World'. An average elevation in excess of 4,500 metres leaves most people struggling in the oxygen-poor air, but for the area’s Tibetan inhabitants life there is as natural as, well, breathing.
Now scientists think they discovered exactly how the Tibetans cope, tracing a specialized gene found in modern-day inhabitants of the region back to one of our extinct ancestors – an ancient species of humanity known as the Denisovans.
The gene itself is known as EPAS-1 and helps to regulate the body’s responses to low-oxygen atmospheres. When most humans are exposed to these conditions their bodies start producing extra red blood cells to circulate more oxygen around the body. However, this creates thicker blood that’s harder to pump and so exacerbates a number of health issues ranging from hypertension to the risk of stroke.
EPAS-1 manages this ‘overreaction’, with one variant allowing responding with less panic to more challenging atmospheres, an effect that has led some scientists to refer to it as the 'athlete' or 'sports' gene - with humans that possess it tending to perform better at certain aerobic-intensive activities.
However, for Tibetans, it’s just part of their ordinary genetic makeup and is found in 87 per cent of the population. This is a stark comparison with the neighbouring Han Chinese, just nine per cent of whom possess EPAS-1.
In the high altitude regions of the Tibetan Plateau air contains 40 per cent less oxygen.
So where did EPAS-1 come from? A new study from the University of Berkeley published in the journal Nature this Wednesday suggests it might have been evolved by the Denisovans – an early human ancestor that was only discovered four years ago when scientists sequenced the DNA from a finger bone found in a Siberian cave.
Denisovans are thought to have been around on the planet for tens of thousands of years longer than modern humans. When the two species bred together some of the ancestors of modern humans inherited the EPAS-1 gene and were able to thrive in the Tibetan plateau – a much faster method of adapting to the high altitude environment than waiting around for evolution to kick in.
This theory of gene acquisition is reinforced by the clear genetic differences between the Tibetans and the neighbouring Han Chinese. “They are extremely differentiated from each other, which is something you only see with very strong or very recent selection,” Rasmus Nielsen, an author of the study, told the LA Times.
The discovery suggests that contrary to older theories that say our ancestors simply out-survived or out-lived more ‘archaic’ humans, it might have been the interbreeding of different species in the Homo genus that helped modern humans survive, offering our ancestors unique genetic 'gifts' that let them adapt to vastly different environments around the world.
- 1 Nigel Farage: Me vs Russell Brand on Question Time – he's got the chest hair but where are his ideas?
- 2 Harry Potter fans can apply to the Hogwarts-inspired College of Wizardry
- 3 Jessica Chambers: 19-year-old woman 'doused with lighter fluid and burned alive' in the US
- 4 Russell Brand calls Nigel Farage 'poundshop Enoch Powell' in BBC Question Time debate
- 5 Orange Wednesdays are no more
Weather bomb in pictures: Storms cuts power for tens of thousands – and snow is on the way
Jessica Chambers: 19-year-old woman 'doused with lighter fluid and burned alive' in the US
Russell Brand calls Nigel Farage 'poundshop Enoch Powell' in BBC Question Time debate
Russell Brand was rendered speechless on Question Time by this man
Fury at Airbus after it hints the super-jumbo may be mothballed
Disgruntled RBS worker writes hilarious open letter to Russell Brand after anti-capitalist publicity stunt leaves him hungry
Nigel Farage defends Kerry Smith 'ch***y' comment: 'If you are going for a Chinese, what do you say you’re going for?'
Nigel Farage's approval rating hits 'record low' as popularity suffers in wake of Ukip sex scandal
Pakistan school attack live: Taliban kill at least 132 children in 'horrifying' massacre
Sony hack: Angelina Jolie branded 'seriously out of her mind' in further embarrassing leaked email saga
Panic Saturday: 13 million Britons spend £1.2bn – while 13 million others across the country live in poverty unable to afford food
£30000 - £35000 per annum: Recruitment Genius: An opportunity has arisen for a...
£30000 - £35000 per annum: Recruitment Genius: An exciting opportunity to join...
£30000 - £35000 per annum: Recruitment Genius: We have an excellent role for a...
Negotiable: Recruitment Genius: An IT Support Analyst is required to join the ...