David Cameron issued a heartfelt personal appeal today for information about missing schoolgirl April Jones.
The Prime Minister said the disappearance was "every family's nightmare" and urged anybody who knew anything about it to contact the police.
"My heart just goes out to April's family. This is every family's nightmare, having this happen and the fact that she suffers from cerebral palsy, something I know a little about from my own children, only makes this worse," he said.
"My appeal would be to everyone, if you know anything, if you saw anything, heard anything, have any ideas you can bring forward, talk to the police, help this family find their lovely child."
Mr Cameron's son Ivan, who suffered with cerebral palsy and epilepsy, died aged 6 in 2009.
Wales' First Minister Carwyn Jones said he had also struggled to comprehend April's sudden disappearance.
Speaking to BBC Wales, Mr Jones said: "As a dad I have thought about little else since the news came through.
"It's very difficult to imagine what April's parents are going through, there's been a lot of support from the community, it's been absolutely incredible.
"So many people have come forward to offer their services, but what we need more than anything else is to understand the whereabouts of April."