A man was found lying in the street with fatal stab wounds in the early hours of today, police said.
Wiltshire Police launched a murder inquiry after the man, who was aged around 40, was found injured in Barnum Court, Rodbourne, Swindon, at around 1.30am and later died in hospital.
Two men, both aged 18, were arrested after being stopped by officers near the scene and have been taken to separate police stations in the area for questioning, a police spokesman said.
Officers, who had been called to the scene following reports of an assault, gave the injured man first aid until the ambulance service arrived shortly afterwards.
The police spokesman said: "The victim was taken to Great Western Hospital where he was pronounced dead at 2.20am.
"Detectives are trying to confirm the identity of the man and trace his next of kin."
A post-mortem examination was expected to take place this morning.
A forensic examination of the scene is being carried out and police cordons have been set up, with Manton Street and Thomas Street currently closed.
Officers have been speaking to witnesses and residents in the area but are appealing for the public to come forward.
Senior investigating officer Detective Inspector Matt Davey said: "We would like to hear from anyone who may have seen or heard anything between 1am and 1.45am in the area of Barnum Court, Swindon.
"If you heard anything or saw someone running away from the scene at that time, you may have vital information that would assist us with this murder investigation."
A major incident room has been set up at Gablecross police station. Anyone with information is urged to call 101 or Crimestoppers, anonymously, on 0800 555 111.