First patented in 1944 as a nasal decongestant, 1-3 di-methylhexanamine (DMAA) has recently become a popular dietary supplement promoting fat loss and boosting energy.
Its affects have been compared to caffeine as well as a mild amphetamine. Popular among bodybuilders as well as endurance athletes the substance is outlawed by many professional and amateur sporting bodies. The deaths of two US servicemen during training led to renewed concerns. In April 2012 the United States Food and Drug Administration wrote to manufacturers including the makers of Jack3D noting that DMA caused blood vessels and arteries to narrow, raised blood pressure and possible heart attack. In August it was reclassified as a medicine in the UK.