International Conference on Aids: New therapy aims to use body's own anti-HIV cell

A NEW approach to Aids therapy which uses the body's own immune system to keep the HIV virus 'locked up' in infected cells is being developed.

Researchers in California have identified a cell in the immune system which stops replication of the virus, it was revealed at the conference yesterday. It attacks infected cells and kills the virus.

The onset of symptoms in HIV and Aids is marked by a drop in the activity of this cell, known as CD8, according to Jay Levy, Professor of medicine at University College San Francisco. He and his team have shown that CD8 activity is strong in HIV positive people who remain healthy.

It appears that the CD8 mechanism is also responsible for reducing HIV replication. High levels of HIV are found very soon after infection but then drop. Professor Levy said that a drop in CD8 cell activity precedes the loss of other immune system cells known as CD4 cells, which are a vital part of the body's defence against infection. HIV takes over these cells to replicate itself. It then destroys the CD4 cell.

Professor Levy said: 'We have shown that activity of CD8 cells is important for blocking replication of the Aids virus.' He said the new finding could explain why some people do not become infected with HIV despite repeated high risk behaviour. It is possible that the CD8 mechanism kills the virus very soon after infection. Why CD8 cells should lose this anti-HIV activity is not yet known.

The researchers also have isolated a protein, known as a cytokine, made by CD8 cells. It stops HIV replications in infected cells. They say they will completely purify the cytokine within six months, raising the possibility that it could be used as a drug.

Professor Levy's research has also highlighted the paradoxical role of antibodies in Aids. Antibodies are produced by the immune system. In HIV infection this antibody response declines. And in the later stages of Aids, the antibodies actually help HIV.

Because it replicates so rapidly HIV is constantly developing new genetic strains. By stopping replication CD8 also stops development of new mutants which are resistant to antibodies. 'Emphasis must be given to enhance this cellular immune response. It potentially can permit long-term survival of infected indivdiudals,' Professor Levy said.

News
Jennifer Lawrence was among the stars allegedly hacked
peopleActress and 100 others on 'master list' after massive hack
Sport
Radamel Falcao
footballManchester United agree loan deal for Monaco striker Falcao
Sport
Louis van Gaal, Radamel Falcao, Arturo Vidal, Mats Hummels and Javier Hernandez
footballFalcao, Hernandez, Welbeck and every deal live as it happens
Voices
A man shoots at targets depicting a portrait of Russian President Vladimir Putin, in a shooting range in the center of the western Ukrainian city of Lviv
voicesIt's cowardice to pretend this is anything other than an invasion
PROMOTED VIDEO
Have you tried new the Independent Digital Edition apps?
News
ebooksAn unforgettable anthology of contemporary reportage
Arts and Entertainment
Alex Kapranos of Franz Ferdinand performs live
music Pro-independence show to take place four days before vote
News
people'It can last and it's terrifying'
Arts and Entertainment
booksNovelist takes aim at Orwell's rules for writing plain English
Arts and Entertainment
The eyes have it: Kate Bush
music
News
Fifi Trixibelle Geldof with her mother, Paula Yates, in 1985
people
News
i100
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Primary Teacher

£100 - £130 per day + Excellent rates of pay, Free CPD: Randstad Education Sou...

Supply Teachers Required

£100 - £130 per day + Excellent rates of Pay, Excellent CPD : Randstad Educati...

NQT and Experienced Primary Teachers Urgently required

£90 - £150 per day: Randstad Education Leeds: NQT and Experienced Primary Teac...

Year 1 Teacher

£100 - £130 per day + Excellent rates of pay, Free CPD: Randstad Education Sou...

Day In a Page

Alexander Fury: The designer names to look for at fashion week this season

The big names to look for this fashion week

This week, designers begin to show their spring 2015 collections in New York
Will Self: 'I like Orwell's writing as much as the next talented mediocrity'

'I like Orwell's writing as much as the next talented mediocrity'

Will Self takes aim at Orwell's rules for writing plain English
Meet Afghanistan's middle-class paint-ballers

Meet Afghanistan's middle-class paint-ballers

Toy guns proving a popular diversion in a country flooded with the real thing
Al Pacino wows Venice

Al Pacino wows Venice

Ham among the brilliance as actor premieres two films at festival
Neil Lawson Baker interview: ‘I’ve gained so much from art. It’s only right to give something back’.

Neil Lawson Baker interview

‘I’ve gained so much from art. It’s only right to give something back’.
The other Mugabe who is lining up for the Zimbabwean presidency

The other Mugabe who is lining up for the Zimbabwean presidency

Wife of President Robert Mugabe appears to have her sights set on succeeding her husband
The model of a gadget launch: Cultivate an atmosphere of mystery and excitement to sell stuff people didn't realise they needed

The model for a gadget launch

Cultivate an atmosphere of mystery and excitement to sell stuff people didn't realise they needed
Alice Roberts: She's done pretty well, for a boffin without a beard

She's done pretty well, for a boffin without a beard

Alice Roberts talks about her new book on evolution - and why her early TV work drew flak from (mostly male) colleagues
Get well soon, Joan Rivers - an inspiration, whether she likes it or not

Get well soon, Joan Rivers

She is awful. But she's also wonderful, not in spite of but because of the fact she's forever saying appalling things, argues Ellen E Jones
Doctor Who Into the Dalek review: A classic sci-fi adventure with all the spectacle of a blockbuster

A fresh take on an old foe

Doctor Who Into the Dalek more than compensated for last week's nonsensical offering
Fashion walks away from the celebrity runway show

Fashion walks away from the celebrity runway show

As the collections start, fashion editor Alexander Fury finds video and the internet are proving more attractive
Meet the stars of TV's Wolf Hall... and it's not the cast of the Tudor trilogy

Meet the stars of TV's Wolf Hall...

... and it's not the cast of the Tudor trilogy
Weekend at the Asylum: Europe's biggest steampunk convention heads to Lincoln

Europe's biggest steampunk convention

Jake Wallis Simons discovers how Victorian ray guns and the martial art of biscuit dunking are precisely what the 21st century needs
Don't swallow the tripe – a user's guide to weasel words

Don't swallow the tripe – a user's guide to weasel words

Lying is dangerous and unnecessary. A new book explains the strategies needed to avoid it. John Rentoul on the art of 'uncommunication'
Daddy, who was Richard Attenborough? Was the beloved thespian the last of the cross-generation stars?

Daddy, who was Richard Attenborough?

The atomisation of culture means that few of those we regard as stars are universally loved any more, says DJ Taylor