International Conference on Aids: New therapy aims to use body's own anti-HIV cell

A NEW approach to Aids therapy which uses the body's own immune system to keep the HIV virus 'locked up' in infected cells is being developed.

Researchers in California have identified a cell in the immune system which stops replication of the virus, it was revealed at the conference yesterday. It attacks infected cells and kills the virus.

The onset of symptoms in HIV and Aids is marked by a drop in the activity of this cell, known as CD8, according to Jay Levy, Professor of medicine at University College San Francisco. He and his team have shown that CD8 activity is strong in HIV positive people who remain healthy.

It appears that the CD8 mechanism is also responsible for reducing HIV replication. High levels of HIV are found very soon after infection but then drop. Professor Levy said that a drop in CD8 cell activity precedes the loss of other immune system cells known as CD4 cells, which are a vital part of the body's defence against infection. HIV takes over these cells to replicate itself. It then destroys the CD4 cell.

Professor Levy said: 'We have shown that activity of CD8 cells is important for blocking replication of the Aids virus.' He said the new finding could explain why some people do not become infected with HIV despite repeated high risk behaviour. It is possible that the CD8 mechanism kills the virus very soon after infection. Why CD8 cells should lose this anti-HIV activity is not yet known.

The researchers also have isolated a protein, known as a cytokine, made by CD8 cells. It stops HIV replications in infected cells. They say they will completely purify the cytokine within six months, raising the possibility that it could be used as a drug.

Professor Levy's research has also highlighted the paradoxical role of antibodies in Aids. Antibodies are produced by the immune system. In HIV infection this antibody response declines. And in the later stages of Aids, the antibodies actually help HIV.

Because it replicates so rapidly HIV is constantly developing new genetic strains. By stopping replication CD8 also stops development of new mutants which are resistant to antibodies. 'Emphasis must be given to enhance this cellular immune response. It potentially can permit long-term survival of infected indivdiudals,' Professor Levy said.

News
people

Arts and Entertainment
JJ Abrams' seventh Star Wars, The Force Awakens
filmsThe first glimpse of Episode VII has gone online after weeks of anticipation
News
Michael Buerk in the I'm A Celebrity jungle 2014
people
Arts and Entertainment
The cast of Downton Abbey in the 2014 Christmas special
art

Presents unwrapped, turkey gobbled... it's time to relax

PROMOTED VIDEO
Have you tried new the Independent Digital Edition apps?
News
ebooksNow available in paperback
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Recruitment Genius: Skilled Machinist

Negotiable: Recruitment Genius: They are in need of additional skilled machini...

Recruitment Genius: Toolmaker

Negotiable: Recruitment Genius: They are in need of additional skilled toolmak...

Langley James : Head of IT; e-commerce; Blackburn; up to £55k

£50000 - £55000 per annum: Langley James : Head of IT; e-commerce; Blackburn; ...

Recruitment Genius: Sales Manager

£25000 - £30000 per annum: Recruitment Genius: If you have experience of B2B s...

Day In a Page

Homeless Veterans Christmas Appeal: ‘We give them hope. They come to us when no one else can help’

Christmas Appeal

Meet the charity giving homeless veterans hope – and who they turn to when no one else can help
Should doctors and patients learn to plan humane, happier endings rather than trying to prolong life?

Is it always right to try to prolong life?

Most of us would prefer to die in our own beds, with our families beside us. But, as a GP, Margaret McCartney sees too many end their days in a medicalised battle
Thomas Cook's outgoing boss Harriet Green got by on four hours sleep a night - is that what it takes for women to get to the top?

What does it take for women to get to the top?

Thomas Cook's outgoing boss Harriet Green got by on four hours sleep a night and told women they had to do more if they wanted to get on
Christmas jumper craze: Inside the UK factory behind this year's multicultural must-have

Knitting pretty: British Christmas Jumpers

Simmy Richman visits Jack Masters, the company behind this year's multicultural must-have
French chefs have launched a campaign to end violence in kitchens - should British restaurants follow suit?

French chefs campaign against bullying

A group of top chefs signed a manifesto against violence in kitchens following the sacking of a chef at a Paris restaurant for scalding his kitchen assistant with a white-hot spoon
Radio 4 to broadcast 10-hour War and Peace on New Year's Day as Controller warns of cuts

Just what you need on a New Year hangover...

Radio 4 to broadcast 10-hour adaptation of War and Peace on first day of 2015
Cuba set to stage its first US musical in 50 years

Cuba to stage first US musical in 50 years

Claire Allfree finds out if the new production of Rent will hit the right note in Havana
Christmas 2014: 10 best educational toys

Learn and play: 10 best educational toys

Of course you want them to have fun, but even better if they can learn at the same time
Paul Scholes column: I like Brendan Rodgers as a manager but Liverpool seem to be going backwards not forwards this season

Paul Scholes column

I like Brendan Rodgers as a manager but Liverpool seem to be going backwards not forwards this season
Lewis Moody column: Stuart Lancaster has made all the right calls – now England must deliver

Lewis Moody: Lancaster has made all the right calls – now England must deliver

So what must the red-rose do differently? They have to take the points on offer 
Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

It's in all our interests to look after servicemen and women who fall on hard times, say party leaders
Millionaire Sol Campbell wades into wealthy backlash against Labour's mansion tax

Sol Campbell cries foul at Labour's mansion tax

The former England defender joins Myleene Klass, Griff Rhys Jones and Melvyn Bragg in criticising proposals
Nicolas Sarkozy returns: The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?

Sarkozy returns

The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?
Is the criticism of Ed Miliband a coded form of anti-Semitism?

Is the criticism of Miliband anti-Semitic?

Attacks on the Labour leader have coalesced around a sense that he is different, weird, a man apart. But is the criticism more sinister?
Ouija boards are the must-have gift this Christmas, fuelled by a schlock horror film

Ouija boards are the must-have festive gift

Simon Usborne explores the appeal - and mysteries - of a century-old parlour game