Progress in search for Aids vaccine: Final phase trials likely to begin next year
Thursday 10 June 1993
Two candidate vaccines have been identified, both of which trigger a strong immune system response over several months to more than one strain of the virus, with minimal side effects in healthy volunteers. The level of antibodies produced is similar to that seen in people infected with the live HIV virus.
The vaccines have progressed to phase two trials - the only two vaccines to have done so - in healthy high-risk volunteers. Plans to recruit thousands more healthy volunteers in the US for the third and final phase of trials are under way for 1994 and 1995.
Dr Dani Bolognesi, director of the Central Immunology Laboratory at Duke University, North Carolina, told the international Aids conference in Berlin: 'HIV vaccine development can be considered at a crossroads, and is in a position to turn a corner'. Another 20 candidate vaccines are in preliminary trials worldwide.
Reports of promising vaccines are a feature of every Aids conference, but Dr Bolognesi gave the most positive report to date.
The two vaccines, known as rgp 120MN and rgp 120 SF-2, trick the body into thinking HIV has infected it. To imitate HIV, scientists used genetic engineering techniques to recreate the outer coat of the virus. The immune system should respond by producing cells which target and destroy HIV. Refinements in the genetic engineering technique used to produce parts of the viral coat mean they now mimic the live virus much more closely than early attempts.
Three doses of rgp 120MN vaccine given over six months stimulated antibodies to three strains of the virus. Three doses of the second vaccine also produced high levels of antibodies to three different strains.
- 1 Five-year-old Iris Grace is raising awareness of autism through her extraordinary paintings
- 2 Expert urges cat lovers to own just one animal each
- 3 Sainsbury's '50p challenge' poster telling staff to encourage customers to spend more placed in shop window instead of staff room
- 4 Yes, the iPhone 6 is a miracle, but it's Apple's tax affairs that deserve a double take
- 5 Car tax disc changes: Two days to go - and they affect you much more than just not displaying a piece of paper
Isis could become 'world’s first truly terrorist state' and bomb UK with nuclear and chemical weapons, Theresa May warns
Car tax disc changes: Five facts you never knew about your (almost obsolete) tax disc
Five-year-old Iris Grace is raising awareness of autism through her extraordinary paintings
Car tax disc changes: Two days to go - and they affect you much more than just not displaying a piece of paper
Isis an hour away from Baghdad - with no sign of Iraq army being able to make a successful counter-attack
Isis, we are told, is a 'clear and dangerous threat to our way of life'. I’m sorry, but I just don’t buy it
Exclusive: 'Putin's Russia has been my biggest regret,' says Nato's outgoing Secretary General
The Osborne Ultimatum: Chancellor’s benefits freeze bombshell will affect ten million households
There’s no excuse for Dave Lee Travis’s behaviour, but we need to keep a sense of proportion
Should gay sex be illegal? 16% of Britons think so
Mark Reckless becomes second Tory MP to defect to Ukip in a month
- < Previous
- Next >
Very Competitive Salary: Austen Lloyd: NORTH HAMPSHIRE NQ to MID LEVEL - An e...
Highly Attractive Pakage: Austen Lloyd: MANCHESTER - A highly attractive oppor...
£40000 - £50000 per annum: Ashdown Group: Marketing Manager (Campaigns, Offlin...
£90000 - £135000 per annum: Ashdown Group: Head of Marketing (B2C, Acquisition...