South African newspapers are already drawing parallels between the situations of Tibetans under Chinese rule and black South Africans under the racist apartheid regime that ended in 1994.
The tensions over the Dalai Lama's visa application are also a sign of how powerful China's influence has become in Africa.
"Our leadership has a clear choice: to look deep into the African soul and emulate (Nelson) Mandela's actions by extending a hand of friendship, while at the same time understanding that it won't, in fact, have any real impact on our relations with China," said an editorial in the Daily Maverick.
"Or, once again to yield as the people who will submit to the will of another nation, to constrict our spirit and our standing as a moral society, and close our doors on a genuine man of peace and the justified hopes of his people."
The Dalai Lama is due to deliver the inaugural Desmond Tutu International Peace lecture, entitled Peace And Compassion As Catalyst For Change, as part of the October 6-8 birthday celebrations for the Archbishop.
The Desmond Tutu Peace Centre, which invited the Dalai Lama to South Africa, said he first tried to apply for a visa in June but was told it was too far ahead of his trip. Later South African officials said they could not process the visa with a photocopied passport of the Buddhist leader and had to wait for him to submit his original document.
"We've sent letters, following up on a daily basis with phone calls and still are in a situation where there is no response and it's getting us much more anxious," said Peace Centre chief executive Nomfundo Wazala. "We have been patient, but we really feel at this point in time we deserve an answer."
The Dalai Lama fled the Himalayan region in 1959 amid an abortive uprising against Chinese rule and is reviled by Beijing as a separatist. China says Tibet has always been part of its territory, but many Tibetans say the region was virtually independent for centuries.
The 76-year-old leader insists he is only seeking increased autonomy for Tibet, not independence. He gave up his political role in the Tibetan exile movement in March, but he remains its spiritual head, beloved by Buddhists around the world.
The Dalai Lama was welcomed to South Africa on his first visit in 1996 and had a memorable meeting with Mr Mandela, the country's first black and democratically elected president.
But in 2009, the South African government outraged many by banning the Dalai Lama from attending a Nobel laureates' peace conference, saying it would detract attention from the 2010 soccer World Cup.
Archbishop Tutu, revered for the part he played to end apartheid, called it "disgraceful" and accused the government of "shamelessly succumbing to Chinese pressure" - a charge officials denied.
A spokesman for South Africa's foreign affairs department, Clayson Monyela, denied there was any pressure to block the Dalai Lama's visit this year.
He said South African officials had only received a complete visa application on September 20 and it was now being "subjected to the normal visa application processes". The South African High Commission in New Delhi, India, where the application was made, usually issues tourist visas within seven days.
Sonam Tenzing, the Dalai Lama's representative for Africa, disputed the government's account as "totally incorrect". He said the visa application was made on August 29 including a photocopy of the Dalai Lama's passport since he was travelling to Latin America.
Mr Monyela said the application was incomplete until they received the passport itself.
Late yesterday, frustrated officials released three letters written by Desmond Tutu Peace Trust chairman Dumisa Ntsebeza to the deputy minister of international relations, Ebrahim I Ebrahim - all of which they said have gone unanswered.
One dated September 7 says the Dalai Lama first tried to apply for a visa in June, when he was told he should reapply nearer the time.
When an attempt was made in July, it said the South African High Commission refused to accept the application, saying it needed "clearance from (officials in) Pretoria".
It said Archbishop Tutu and his representatives have approached a number of senior government members "but nobody seemed willing to engage the matter" even after Mr Ntsebeza discussed it with President Jacob Zuma.
"Neither Archbishop Tutu nor the Peace Centre is insensitive to the challenges government may face from China..." the letter says.
South African officials may be especially squeamish following Beijing's furious response to Mexico's President Felipe Calderon meeting the Dalai Lama earlier this month.
The meeting "grossly interfered with China's internal affairs, hurt the feelings of the Chinese people and harmed Chinese-Mexican relations", Chinese Foreign Ministry spokesman Ma Zhaoxu said.
China was equally strident when US President Barack Obama received the Dalai Lama at the White House in July, ignoring Chinese warnings.
"We demand the US side seriously consider China's stance, immediately adopt measures to wipe out the baneful impact, stop interfering in China's internal affairs and cease to connive and support anti-China separatist forces that seek 'Tibetan independence'," Mr Ma said at the time.
China-Africa expert Martyn Davies said China's concern seemed to be over meetings with high-ranking officials.
"If the Dalai Lama does come to South Africa, I do not see any reason for the Dalai Lama to meet with President Zuma or any other South African government official. He is a religious figure but with an overly politicised persona," Mr Davies said by email from Beijing.
Chinese Foreign Ministry spokesman Hong Lei would not say if China has talked to South Africa about the trip, but he told a daily news conference that "China's position of opposing the Dalai Lama visiting any country with ties to China is clear and consistent".
In March 2009, Mr Zuma said the real problem was the timing of the Dalai Lama's visit - the 50th anniversary of the Buddhist leader's flight into exile. Mr Zuma became president of South Africa soon afterwards.
"Well, Zuma is now in charge of the government, the Dalai Lama has been invited again, and this time the invitation is not for March but for October. So what about it, Mr President?" the Daily News asked.
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