The US military said two heavily armed people were in custody after trying to enter MacDill Air Force Base outside Tampa.
The base is home to US Central Command, which runs the US wars in Afghanistan and Iraq.
Base spokeswoman Katherine B. Holt said a man and woman were unable to show proper identification, and their vehicle was searched.
Security found military-style gear and weapons in their sport utility vehicle. Ms Holt said she did not know how many weapons were removed.
The suspects' names were not released.
The military said the base was operating normally.Reuse content