Baby born after infertile woman has ovaries 'reawakened'

 

A previously infertile woman has given birth to a healthy baby, after scientists discovered a way to beat the menopause by inducing ovaries to produce eggs.

The 30-year-old woman gave birth to a son in Tokyo last December and another woman is also now pregnant using the same technique. Researchers in the US and Japan believe it could offer new hope to women who run out of eggs early in life, in findings described as a "game changer".

The study, reported in the Proceedings of the National Academy of Sciences used 27 female participants who had been diagnosed with primary ovarian insufficiency, an uncommon form of infertility sometimes referred to as early menopause.

It appears in approximately 1 in 100 women of a child-bearing age. The cause of most cases is unknown, but the outcome is that the ovary has trouble producing eggs.

A US team based at Stanford University and a team of researchers from the St Marianna University School of Medicine in Japan, worked to activate the few remaining follicles - eggs in the ovaries which are not fully formed.

They removed the ovaries from the women and applied two techniques to 'wake up' the dormant follicles.

First, the women's ovaries were cut into strips, which were frozen. Later the strips were thawed and cut into tiny cubes, a step intended to stimulate maturation of the follicles.

Then the cubes were treated with drugs to encourage further development of the follicles. Cubes were then transplanted just under the surface of the women's fallopian tubes.

Within six months, eight women showed signs of follicle maturation, and five of them produced eggs for fertilization in the lab with their husbands' sperm. The fertilized eggs were grown into early embryos, which were frozen for preservation.

Dr. Kazuhiro Kawamura of the St. Marianna University School of Medicine said the woman and her child were both in good health.

After the experimental procedure, Kawamura and colleagues were able to recover eggs from five of their 27 patients. One woman went on to have a miscarriage, one did not get pregnant, and two more have not yet attempted pregnancy.

Aaron Hsueh of Stanford University, senior author of the study, said researchers found that half the 27 patients had no follicles at all, which meant the treatment could not help them and needed to be developed further.

Speaking to the BBC, Prof Hsueh said: “It has to be improved to figure out the best way to do it, but we estimate it could help 25 to 30% of the women.

“We think it could help in two other forms of infertility. Cancer survivors after chemotherapy or radiotherapy; if there's any follicles left there's a chance this will help."

Kawamura released a photo of himself holding the newborn shortly the child's delivery. He said the mother hopes to have another child using the same technique.

Sport
Alexis Sanchez has completed a £35m move to Arsenal, the club have confirmed
sportGunners complete £35m signing of Barcelona forward
Life and Style
A binge is classed as four or more alcoholic drinks for women and five or more for men, consumed over a roughly two-hour period
tech
News
Detail of the dress made entirely of loom bands
news
Life and Style
More than half of young adults have engaged in 'unwanted but consensual sexting with a committed partner,' according to research
techResearchers recover 100s of nude photos from second-hand smartphones
PROMOTED VIDEO
Have you tried new the Independent Digital Edition apps?
News
ebookA unique anthology of reporting and analysis of a crucial period of history
Life and Style
It beggars belief: the homeless and hungry are weary, tortured, ghosts of people – with bodies contorted by imperceptible pain
lifeRough sleepers exist in every city. Hear the stories of those whose luck has run out
Life and Style
fashionJ Crew introduces triple zero size to meet the Asia market demand
Sport
Santi Cazorla, Mikel Arteta and Mathieu Flamini of Arsenal launch the new Puma Arsenal kits at the Puma Store on Carnaby Street
sportMassive deal worth £150m over the next five years
Arts and Entertainment
Welsh opera singer Katherine Jenkins
musicHolyrood MPs 'staggered' at lack of Scottish artists performing
Life and Style
beautyBelgian fan lands L'Oreal campaign after being spotted at World Cup
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Head of Digital Marketing,London

To £58k Contract 12 months: Charter Selection: Major household name charity se...

Network Support Engineer / Junior Test Analyst

£23000 - £27000 per annum: Deerfoot IT Resources Limited: A market leading, in...

Key Account Manager, Medical

£35000 per annum, Benefits: Excellent commission structure + Car: Charter Sele...

Key Account Manager, Medical

£35000 per annum, Benefits: Excellent commission structure + Car: Charter Sele...

Day In a Page

A History of the First World War in 100 Moments: Peace without magnanimity - the summit in a railway siding that ended the fighting

A History of the First World War in 100 Moments

Peace without magnanimity - the summit in a railway siding that ended the fighting
Scottish independence: How the Commonwealth Games could swing the vote

Scottish independence: How the Commonwealth Games could swing the vote

In the final part of our series, Chris Green arrives in Glasgow - a host city struggling to keep the politics out of its celebration of sport
Out in the cold: A writer spends a night on the streets and hears the stories of the homeless

A writer spends a night on the streets

Rough sleepers - the homeless, the destitute and the drunk - exist in every city. Will Nicoll meets those whose luck has run out
Striking new stations, high-speed links and (whisper it) better services - the UK's railways are entering a new golden age

UK's railways are entering a new golden age

New stations are opening across the country and our railways appear to be entering an era not seen in Britain since the early 1950s
Conchita Wurst becomes a 'bride' on the Paris catwalk - and proves there is life after Eurovision

Conchita becomes a 'bride' on Paris catwalk

Alexander Fury salutes the Eurovision Song Contest winner's latest triumph
Pétanque World Championship in Marseilles hit by

Pétanque 'world cup' hit by death threats

This year's most acrimonious sporting event took place in France, not Brazil. How did pétanque get so passionate?
Whelks are healthy, versatile and sustainable - so why did we stop eating them in the UK?

Why did we stop eating whelks?

Whelks were the Victorian equivalent of the donor kebab and our stocks are abundant. So why do we now export them all to the Far East?
10 best women's sunglasses

In the shade: 10 best women's sunglasses

From luxury bespoke eyewear to fun festival sunnies, we round up the shades to be seen in this summer
Germany vs Argentina World Cup 2014: Lionel Messi? Javier Mascherano is key for Argentina...

World Cup final: Messi? Mascherano is key for Argentina...

No 10 is always centre of attention but Barça team-mate is just as crucial to finalists’ hopes
Siobhan-Marie O’Connor: Swimmer knows she needs Glasgow joy on road to Rio

Siobhan-Marie O’Connor: Swimmer needs Glasgow joy on road to Rio

18-year-old says this month’s Commonwealth Games are a key staging post in her career before time slips away
The true Gaza back-story that the Israelis aren’t telling this week

The true Gaza back-story that the Israelis aren’t telling this week

A future Palestine state will have no borders and be an enclave within Israel, surrounded on all sides by Israeli-held territory, says Robert Fisk
A History of the First World War in 100 Moments: The German people demand an end to the fighting

A History of the First World War in 100 Moments

The German people demand an end to the fighting
New play by Oscar Wilde's grandson reveals what the Irish wit said at his trials

New play reveals what Oscar Wilde said at trials

For a century, what Wilde actually said at his trials was a mystery. But the recent discovery of shorthand notes changed that. Now his grandson Merlin Holland has turned them into a play
Can scientists save the world's sea life from

Can scientists save our sea life?

By the end of the century, the only living things left in our oceans could be plankton and jellyfish. Alex Renton meets the scientists who are trying to turn the tide
Richard III, Trafalgar Studios, review: Martin Freeman gives highly intelligent performance

Richard III review

Martin Freeman’s psychotic monarch is big on mockery but wanting in malice