Mr Embry said he had not been able to contact Domino since talking to him on Sunday evening by telephone. Domino told Mr Embry that he planned to stay at his house in New Orleans with his wife, Rosemary, and their daughter.
"I hope somebody turns him up, but as of right now, we haven't got anybody that knows where he's at," said Mr Embry, who has worked with Domino for 28 years. "I would think he might be safe because somebody said he was on top of the balcony." Domino, who has rarely appeared in public in recent years, has a home in a low-lying area of the city.
Getting information on possible missing persons has been nearly impossible as telephone lines for hospitals and police have not been working.
Antoine "Fats" Domino has sold more than 110 million records, including the singles "Blueberry Hill" and "Ain't That a Shame". His 1950 recording of "The Fat Man" has been called the first rock'n'roll record.