The truck ran into a popular market in a tourist area, close to Kaiser Wilhelm memorial church.
Video footage posted to social media shows the large dark coloured articulated lorry in the middle of a street decorated for Christmas.
Collapsed structures and Christmas decorations can be seen littering the street, apparently along the path of the lorry’s travel.
Numerous emergency service vehicles attended the scene, securing the area and tending to the injured.
Berlin Christmas market lorry attack
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Eyewitnesses reported that the lorry entered the market "at some speed - perhaps as high as 40mph", knocking down stalls before eventually coming to a standstill.
Emma Rushton, who was at the market at the time, told Sky News: "It wasn't an accident. It was going at 40mph through the middle of the market. There was no way it could have come off the road and it showed no signs of slowing down."
She added: "There were lots and lots of people, this is Monday evening, people had finished work. There were tourists there."
Jan Hollitzer, deputy editor in chief of the Berliner Morgenpost said: "I heard a big noise and then I moved on the Christmas market and saw much chaos...many injured people," "It was really traumatic."
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