Police in Jerusalem will be on high alert as the Temple Mount, also known as the Noble Sanctuary, is reopened this morning after the shooting of a Jewish activist.
The heavily guarded site will only be open to men over the age of 50 and women of all ages in a move police said aimed to prevent demonstrations.
The 35-acre compound is the holiest site in Judaism and contains the al-Aqsa Mosque - the third holiest site in Islam – and the Dome of the Rock.
Israeli authorities closed off the sensitive site on Thursday for the first time in 14 years following the attempted assassination of Yehuda Glick, who had campaigned for greater Jewish access to the area.
His suspected attacker, Moataz Hijazi, was later shot dead by police, sparking angry protests in the Abu Tor district of Jerusalem.
The Palestinian President, Mahmoud Abbas, called the closure of the holy site a “declaration of war”, while Israeli Prime Minister Benjamin Netanyahu called the shooting of Mr Glick an “act of terrorism”.
International politicians called for calm as the crisis threatened to further deteriorate Israel-Palestinian relations after faltering peace talks.
John Kerry, the US Secretary of State, said: “It is absolutely critical that all sides exercise restraint, refrain from provocative actions and rhetoric, and preserve the historic status quo on the Haram al-Sharif/Temple Mount - in word and in practice.”
In pictures: Israeli/Palestinian clashes
In pictures: Israeli/Palestinian clashes
1/10 Israeli/Palestinian clashes
Israeli security and a Palestinian stone thrower clash in the Shuafat neighborhood in Israeli-annexed Arab East Jerusalem
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A Palestinian protestor directs fireworks toward Israeli police during clashes in Shuafat neighborhood in Israeli-annexed Arab East Jerusalem
3/10 Israeli/Palestinian clashes
An Israeli police officer during clashes with Palestinians in Jerusalem
4/10 Israeli/Palestinian clashes
Masked Palestinian protestors take cover as they throw stones toward Israeli police during clashes in Shuafat neighborhood in Israeli-annexed Arab East Jerusalem
5/10 Israeli/Palestinian clashes
Israeli army soldiers take positions during clashes with Palestinians in an early morning in the West Bank city of Jenin
6/10 Israeli/Palestinian clashes
Palestinians set tyres ablaze during clashes with Israeli police in Shuafat, an Arab suburb of Jerusalem July 2, 2014.
7/10 Israeli/Palestinian clashes
A Palestinian argues with Israeli border police in Jerusalem on Wednesday, July 2, 2014.
8/10 Israeli/Palestinian clashes
Palestinian protestors gather behind a barrier as they throw stones toward Israeli police during clashes in the Shuafat neighborhood in Israeli-annexed Arab East Jerusalem, on July 2, 2014, after a Palestinian teenager was kidnapped and killed in an apparent act of revenge for the murder by militants of three Israeli youths.
AHMAD GHARABLI/AFP/Getty Images
9/10 Israeli/Palestinian clashes
Palestinian youths clash with Israeli Police near to the house of murdered Palestinian teenager Mohammed Abu Khdair, in Jerusalem on July 2, 2014 in Jerusalem, Israel.
Ilia Yefimovich/Getty Images
10/10 Israeli/Palestinian clashes
Masked Palestinian protesters throw stones toward Israeli police during clashes in the Shuafat neighborhood in Israeli-annexed Arab East Jerusalem
It is open to Jews and followers of other religions as visitors but only Muslims are allowed to pray at the site.
Mr Glick is a leading voice in efforts to allow Jews to pray inside the mosque compound but some Muslim worshippers view Jewish prayer there as a provocation, fearing that Jewish extremists are plotting to take over the area.
US-born Mr Glick made the same accusation towards Muslims in an interview with the Associated Press, saying: “The more extreme Islamist organisations are taking over and if we don't stop them early enough, they will take over the entire Jerusalem.”
He remains in hospital but his condition was said to be improving on Thursday night.
The contested site lies in East Jerusalem, which was captured by Israel in the Six-Day War of 1967 and remains a focal point of the Arab-Israeli conflict as the Palestinian Authority continues to claim sovereignty.
It is a flashpoint for violence when tensions rise in Israel and the Occupied Palestinian Territories and has seen angry protests over the summer.
The shooting was the latest violence in Jerusalem, coming just days after a three-month-old Israeli-American baby girl was killed when a Palestinian motorist drove his car into a crowded train station.
As well as tensions following the 50-day war in Gaza earlier this year, there is anger over Israel’s plans to press forward with the construction of Jewish settlements in the largely Muslim East Jerusalem.
Tobias Ellwood, minister for the Middle East, said: “The UK condemns the Israeli government’s announcement this week to advance plans for 1,060 new housing units in East Jerusalem.
“This is an ill-judged and ill-timed decision which makes it harder to achieve a two state solution with Jerusalem as a shared capital.
“Such announcements make it more difficult for Israel’s friends to defend it against accusations that it is not serious about peace.”
On Thursday, Sweden formally recognised a Palestinian state, prompting Israel to withdraw its ambassador for Stockholm.
Additional reporting by APReuse content