The eighth-seeded South African lasted just 59 minutes on centre court against the player who who beat the ninth seed, Andre Agassi.
The result means that Boris Becker, beaten by Spain's Carlos Moya in the second round on Wednesday, is assured of his place in the eight-man ATP Tour World Championship in Hanover next month, where he will defend the title.
Pete Sampras, Michael Chang, Goran Ivanisevic, Yevgeny Kafelnikov and Thomas Muster have already gained a spot for the end of year event which starts on 19 November.
Stefan Edberg rallied to beat the Dutch qualifier Fernon Wibier 4-6, 6-4, 6-2. The Swede, ranked 17th in the world but unseeded in the tournament, lost the first set but recovered, taking 10 of the last 13 games.
Monica Seles showed no ill-effects from a sore shoulder or a month's lay-off as she beat Elena Likhovtseva 6-2, 6-1 in 49 minutes in the second round of the Ameritech Cup in Chicago. The world joint No 1 will put off surgery to repair a tear in her shoulder, which would keep her out of the game for at least 12 weeks, for as long as possible.Reuse content