The former World Boxing Organisation middleweight and super-middleweight champion finished off Camilio Hernando Alarcon in the fourth round of their light-heavyweight contest.
The Brighton boxer's second victory of his comeback was achieved with relative ease before an audience of about 1,000 at the Dubai Aviation Club. Although Alarcon had not fought for a year, he managed to catch Eubank in the third round, but the former world champion responded with a barrage of blows that had his opponent on the canvas in 2min 36sec of the fourth.
Eubank, who made his entrance into the 7,000 capacity arena on a crane, launched his return to boxing with a victory in Cairo last October and now hopes to fight for a world title in two months' time, probably in neighbouring Abu Dhabi.
"He was big puncher, but just as I was preparing to accept some of the punishment, he left himself open. I came in and let go a barrage of punches," he said. "The first one caught him and when the second caught him as well, it set off a roll and I was firing some hard shots, overhead, left and rights.
"I rated him. You don't get to No 6 in the world by being a nobody. In the Cairo fight my opponent Luis Barrera had a good record, but was a poor performer. But this man came to fight and had some very heavy punches."
Ryan Rhodes, the light-middleweight title holder who is Britain's youngest champion for 57 years, has been voted the Best Young Boxer of the Year by the Boxing Writers' Club.